The aim of this study was to validate the Hammersmith functional motor scale for children with spinal muscular atrophy in a large cohort of 90 non-ambulant children with spinal muscular atrophy type 2 or 3. All had a baseline assessment (T0) and were reassessed either at 3 months (T1) (n=66) or at 6 months (T2) (n=24). Inter-observer reliability, tested on 13 children among 3 examiners, was >95%. Of the 66 children examined after 3 months 4 had adverse effects in between assessments and were excluded from the analysis. Forty-two (68%) of the remaining 62 reassessed had no variation in scores between T0 and T1 and 13 (21%) were within ±1 point. 9 (37.5%) of the 24 children reassessed after 6 months had no variation in scores between T0 and T2 and another 9 (37.5%) had variations within ±1 point. Our study confirms previous observations of the reliability of the scale and helps to establish a baseline for assessing changes of functional ability over 3 and 6 month intervals. This information can be valuable in view of therapeutic trials. © 2005 Elsevier B.V. All rights reserved.

Mercuri, E. M., Messina, S., Battini, R., Berardinelli, A., Boffi, P., Bono, R., Bruno, C., Carboni, N., Cini, C., Colitto, F., D'Amico, A., Minetti, C., Mirabella, M., Mongini, T., Morandi, L., Dlamini, N., Orcesi, S., Pelliccioni, M., Pane, M., Pini, A., Swan, A. V., Villanova, M., Vita, G., Main, M., Muntoni, F., Bertini, E. S., Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study, <<NEUROMUSCULAR DISORDERS>>, 2006; 16 (2): 93-98. [doi:10.1016/j.nmd.2005.11.010] [https://hdl.handle.net/10807/260321]

Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study

Mercuri, Eugenio Maria;Battini, Roberta;Colitto, Francesca;Mirabella, Massimiliano;Pane, Marika;Bertini, Enrico Silvio
2006

Abstract

The aim of this study was to validate the Hammersmith functional motor scale for children with spinal muscular atrophy in a large cohort of 90 non-ambulant children with spinal muscular atrophy type 2 or 3. All had a baseline assessment (T0) and were reassessed either at 3 months (T1) (n=66) or at 6 months (T2) (n=24). Inter-observer reliability, tested on 13 children among 3 examiners, was >95%. Of the 66 children examined after 3 months 4 had adverse effects in between assessments and were excluded from the analysis. Forty-two (68%) of the remaining 62 reassessed had no variation in scores between T0 and T1 and 13 (21%) were within ±1 point. 9 (37.5%) of the 24 children reassessed after 6 months had no variation in scores between T0 and T2 and another 9 (37.5%) had variations within ±1 point. Our study confirms previous observations of the reliability of the scale and helps to establish a baseline for assessing changes of functional ability over 3 and 6 month intervals. This information can be valuable in view of therapeutic trials. © 2005 Elsevier B.V. All rights reserved.
2006
Inglese
Mercuri, E. M., Messina, S., Battini, R., Berardinelli, A., Boffi, P., Bono, R., Bruno, C., Carboni, N., Cini, C., Colitto, F., D'Amico, A., Minetti, C., Mirabella, M., Mongini, T., Morandi, L., Dlamini, N., Orcesi, S., Pelliccioni, M., Pane, M., Pini, A., Swan, A. V., Villanova, M., Vita, G., Main, M., Muntoni, F., Bertini, E. S., Reliability of the Hammersmith functional motor scale for spinal muscular atrophy in a multicentric study, <<NEUROMUSCULAR DISORDERS>>, 2006; 16 (2): 93-98. [doi:10.1016/j.nmd.2005.11.010] [https://hdl.handle.net/10807/260321]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/260321
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