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The risk of cardiovascular events in the Italian adult population without prior history of CVD: a systematic review of follow-up studies

Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity in Europe. Understanding their burden is essential to planning effective public health responses. However, in Italy, comprehensive data on the incidence and lethality of major cardiovascular events, including myocardial infarction and stroke, are fragmented and heterogeneous. This review aims to assess the incidence of fatal and non-fatal major cardiovascular events in Italian adults without prior C...

Cost-effectiveness analysis of lorlatinib as first-line treatment for anaplastic lymphoma kinase (ALK)-positive non–small cell lung cancer in Italy

Background: Lorlatinib is a third-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) with high central nervous system penetration and activity against resistance mutations. Although its clinical efficacy as first-line treatment for ALK-positive advanced non–small cell lung cancer (NSCLC) has been demonstrated, its economic value within the Italian healthcare system remains to be fully established. This study evaluated the cost-effectiveness of lorlatinib compared with...

Budget Impact Analysis of Pulsed Field Versus Cryoballoon and Laser Procedures for Atrial Fibrillation in Italy

Background and ObjectivesAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with a higher prevalence due to the ageing of the population. Traditional ablation techniques, such as cryoballoon ablation (CB) and laser ablation (LA), are widely used but may be associated with longer procedure times and a risk of collateral tissue injury. Pulsed field ablation (PFA) is an emerging non-thermal technology that uses electroporation, with early evidence suggesting a favourable s...

Effect of discontinuing antipsychotic medications on the risk of hospitalization in long-term care: a machine learning-based analysis

Background: Antipsychotic medications are frequently prescribed to older residents of long-term care facilities (LTCFs) despite their limited efficacy and considerable safety risks. While discontinuation of these drugs might help reduce their associated morbidity, the impact of stopping antipsychotics on the risk of hospitalization has not been studied yet. The study aimed at estimating the effect of antipsychotic discontinuation on the risk of hospitalization in older LTCF residents and at i...

Outcome measures for health interventions targeting multimorbid older adults: A systematic review

Background: Older adults with multimorbidity are often excluded from clinical trials. Traditional disease-centered endpoints may be inadequate for this population, presenting unique challenges related to frailty, functional decline and disability. Objectives: To systematically review the literature on outcomes considered relevant in interventions targeting older adults with multimorbidity, based on both patient and healthcare professionals' perspectives. Methods: This systematic review follow...

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