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La domanda di Leibniz e la concezione tomistica dell'essere nel pensiero di Vittorio Possenti

My disagreement with Possenti's ontological position regards mainly the following two points: 1) the self-contradictoriness, asserted by me and negated by him, of the statement "nothing exists"; 2) the ontological status of the analogy of attribution, which he considers to be a kind of univocity whereas I think it is the true form of analogy, superior to the analogy of proportionality.

Noterelle sull'adattamento anglo-normanno della prima versione francese del De lapidibus di Marbodo di Rennes

This article examines the Anglo-Norman adaptation of the first French version of Marbode of Rennes’ De lapidibus. Through the analysis of manuscript relationships and textual features, it highlights processes of reorganization, integration, and expansion within the text. The study shows how the adaptation reflects a context of compilation and practical recontextualization, contributing to a better understanding of the transmission and transformation of lapidary material in the Anglo-Norman mi...

Metabolic pathways regulated by p63

The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ΔNp63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic rep...

Kruppel-like factor 4 regulates keratinocyte senescence

Keratinocyte replicative senescence has an important role in time-related changes of epidermis. Previous studies demonstrated that miRNAs play key roles in inhibiting proliferation and in the acquisition of the keratinocyte senescent phenotype as well as in individual ageing. Kruppel-like factor 4 is a transcription factor with dual functions in keratinocytes, being a stemness factor and a pro-differentiation factor. Interestingly, in skin squamous cell carcinomas KLF4 expression is strongly ...

ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development

Development and maintenance of healthy stratified epithelia require the coordination of complex transcriptional programmes. The transcription factor p63, a member of the p53 family, plays a crucial role in epithelial development and homeostasis. Analysis of the p63-dependent transcriptome indicated that one important aspect of p63 functions in epithelial development is the regulation of cell–cell and cell–matrix adhesion programmes. However, limited knowledge exists on the relevant cell–cell ...

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