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A Wearable-Derived Autonomic Component Is Associated with Cardiovascular Health in Community-Dwelling Adults: A Cross-Sectional Analysis from the Longevity Check-Up 8+ Study

Background/Objectives: Wearable devices provide multidimensional measures of cardiometabolic health. We aimed to derive latent physiological dimensions from ECG and motion variables collected by a wearable device and evaluate their associations with the individual health metrics of the Longevity Check-Up 8+ (LC8+) programme. Methods: Community-dwelling adults voluntarily participating in four Longevity Check-Up 8+ (LC8+) events underwent 24-h multiparameter recording using a wearable device. ...

Immune-mediated necrotizing myopathies: clinico-serological features and treatment outcomes of a large Italian cohort of patients

Background: Immune-mediated necrotizing myopathy (IMNM) is a distinct entity with limited large-cohort data. We aimed to characterize clinico-serological features and treatment outcomes of anti-SRP, anti-HMGCR, and seronegative IMNM in a large Italian cohort. Methods: Retrospective multicenter study of adults diagnosed with IMNM (224th ENMC criteria) across 14 Italian neuromuscular centers between 2019 and 2022 was performed. Results: We included 159 subjects (57% female, median age 62 years)...

Tigray, un ritorno alla guerra? Cronaca di una crisi che si riapre

Da alcune settimane la regione del Tigray, nell’Etiopia settentrionale, è nuovamente oggetto dell’attenzione internazionale. La regione era stata teatro, tra il 2020 e il 2022, di uno dei conflitti più sanguinosi degli ultimi decenni nel continente africano. A tre anni dalla firma dell’accordo di pace di Pretoria si osservano oggi una ripresa dei combattimenti, un progressivo indebolimento dell’intesa raggiunta e il riacutizzarsi del rischio di carestia.

The Wider Mediterranean within the Frame of the Great Global Disorder. States, Actors and Geopolitical Drivers in a Changing Region

This book examines the renewed geopolitical and socio-economic centrality of the enlarged Mediterranean within the contemporary global order. It explores the major political, economic and cultural transformations shaping the region, highlighting how the Mediterranean basin has re-emerged as a strategic space marked by regional crises, international competition and complex interdependencies. Adopting a historical and interdisciplinary perspective, the volume analyses the evolving dynamics t...

Continence outcomes of robot-assisted radical prostatectomy in patients with adverse urinary continence risk factors

Objective To analyse the continence outcomes of robot-assisted radical prostatectomy (RARP) in suboptimal patients that have challenging continence recovery factors such as enlarged prostates, elderly patients, higher body mass index (BMI), salvage prostatectomy, and bladder neck procedures before RARP. Patients and Methods From January 2008 through November 2012, 4 023 patients underwent RARP by a single surgeon at our institution. Retrospective analysis of prospectively collected data ident...

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