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Multimodal Signatures of Brain Aging: From Descriptive Analyses to Machine Learning-Based Integration

Understanding age-related neurophysiological changes is crucial for identifying brain aging biomarkers and developing strategies against motor and cognitive decline. To explore aging-related patterns across multiple domains, this study assessed motor and cognitive performance, functional connectivity, and synaptic organization in Young (4 months), Adult (14 months), and Old (24 months) mice. Adult mice exhibited reduced locomotor activity (−50.3%) and forelimb force (−38.3%) compared to ...

Ventral striatal neuroimmune signalling biases the expression of social memory in male mice

Social behaviours are highly sensitive to inflammatory states. However, the precise contribution of neuroinflammation in the ventral striatum to social memory remains unclear. Using a mouse model of recurrent herpes simplex virus-1 (HSV-1) infection and a complementary model of region-restricted inflammation induced by bilateral intra-ventral striatum lipopolysaccharide (LPS) injection, we show that ventral striatal inflammation impacts social memory expression. Both HSV-1-infected and LPS-tr...

A differentiable and uncertainty-aware mutual information regularizer for bias mitigation

Ensuring algorithmic fairness is a central challenge in high-stakes machine learning applications, where biased predictions can have harmful societal consequences. Discrimination may persist even when sensitive features are excluded from model inputs, due to statistical dependencies between protected and ostensibly non-sensitive at tributes that allow bias to be indirectly learned. Mutual information is a principled measure of such dependence, yet its non-differentiability under hard-threshol...

Il visiting advocacy in un Centro Diurno per bambini e ragazzi. Analisi di una esperienza

Il contributo presenta una ricerca qualitativa condotta nell’ambito di un progetto sperimentale per l’introduzione della pratica dell’advocacy professionale indipendente in un Centro diurno per bambini e ragazzi seguiti dai servizi di tutela minorile in Piemonte. Dopo un’iniziale introduzione sul concetto di advocacy a supporto della partecipazione delle persone di minore età ai processi decisionali, il paper presenta i risultati della ricerca che ha studiato il servizio sperimentale attraver...

Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia

Background: Achondroplasia is a genetic skeletal condition caused by FGFR3 pathogenic variants. Infigratinib, an oral FGFR1-3 tyrosine kinase inhibitor, down-regulates key pathways in the pathogenesis of achondroplasia. Methods: In this phase 3, multicenter, double-blind, placebo-controlled trial, we randomly assigned children with achondroplasia (3 to 17 years of age) in a 2:1 ratio to receive infigratinib (at a dose of 0.25 mg per kilogram of body weight) or placebo once daily for 52 weeks....

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Autore
  • Gasbarrini, Antonio1792
  • Scambia, Giovanni1382
  • Locatelli, Franco1265
  • Balconi, Michela1072
  • Crea, Filippo996
  • Reggiani, Enrico930
  • Ricciardi, Walter853
  • Riva, Giuseppe783
  • Sanguinetti, Maurizio708
  • Burzotta, Francesco701
collection
  • Abstract (se pubblicati in Atti d...1674
  • Abstract (se pubblicati su rivista)897
  • Abstract in rivista531
  • Altro339
  • Articolo in rivista, Nota a sentenza70643
  • Articolo su quotidiano1289
  • Articolo su web1000
  • Atti di Convegno, Congresso, Gior...3033
  • Atti di Convegno, Congresso, Gior...143
  • Brevetto26
Data di pubblicazione
  • 2020 - 202641923
  • 2010 - 201961684
  • 2000 - 200923176
  • 1990 - 19995229
  • 1980 - 19891564
  • 1970 - 1979238
  • 1960 - 196919
  • 1955 - 19597
Settore disciplinare
  • Settore M-PED/01 - PEDAGOGIA GENE...3306
  • Settore MED/38 - PEDIATRIA GENERA...3109
  • Settore SPS/07 - SOCIOLOGIA GENERALE2979
  • Settore SPS/08 - SOCIOLOGIA DEI P...2804
  • Settore MED/09 - MEDICINA INTERNA2731
  • Settore MED/26 - NEUROLOGIA2636
  • Settore MED/18 - CHIRURGIA GENERALE2455
  • Settore M-PSI/01 - PSICOLOGIA GEN...2440
  • Settore SECS-P/01 - ECONOMIA POLI...2232
  • Settore M-PSI/05 - PSICOLOGIA SOC...2070
Editore
  • Vita e Pensiero5218
  • Franco Angeli2635
  • Università Cattolica del Sacro Cuore2298
  • Springer1410
  • MDPI1350
  • Giuffrè Editore1173
  • EDUCatt1064
  • Elsevier992
  • Elsevier B.V.983
  • Il Mulino961
Conferenza
  • XXIV Congresso Nazionale della So...17
  • 47° Congresso Nazionale SItI16
  • 6th Meeting of the Federation of ...15
  • 17th World Congress on Ultrasound...13
  • 7th European Public Health Confer...13
  • 8th European Public Health Confer...13
  • XXV Congresso della Società Itali...13
  • 48° Congresso Nazionale SItI – “A...12
  • 7th International Conference on P...12
  • XXIII Congresso Nazionale della S...12
Accesso al fulltext
  • no fulltext117088
  • open15196
  • reserved1112
  • partially open414
  • embargoed24
Keyword
  • Humans5412
  • Female2978
  • Male2613
  • Middle Aged1815
  • Adult1753
  • Aged1571
  • Italy1147
  • COVID-191106
  • Animals702
  • N/A659