https://hdl.handle.net/10807/1 Tue, 28 Jul 2026 07:29:52 GMT 2026-07-28T07:29:52Z https://hdl.handle.net/10807/343757 Titolo: TP53 Mutations Unfavorably Impact the Outcomes of Myelofibrosis Patients with or Without Hematopoietic Stem Cell Transplantation: A Single-Center Study and Meta-Analysis Autori: Frioni, Filippo; Giammarco, Sabrina; Ceglie, Sara; Betti, Silvia; Ramundo, Francesco; Marra, John; Rossi, Monica; Fosso, Federica; Minnella, Gessica; Metafuni, Elisabetta; Sora, Federica; Bacigalupo, Andrea; Sica, Simona; Rossi, Elena; De Stefano, Valerio; Chiusolo, Patrizia Abstract: TP53 mutation is known to be a poor prognostic factor in many hematologic malignancies, but it is not included in any Myelofibrosis-specific prognostic score. Recently, studies have shown that TP53 mutation may negatively impact the outcomes of patients with Myelofibrosis, including those undergoing hematopoietic stem cell transplantation. In this study, we aimed to analyze the impact of TP53 mutation on the overall survival and leukemia-free survival of patients with chronic-phase Myelofibrosis, regardless of whether they had undergone transplantation. A total of 250 patients were included in the study, of whom 9 (3.2%) harbored a TP53 mutation, including six (3.2%) among non-HSCT patients and three (3.1%) among HSCT patients. In both groups, the presence of TP53 mutation correlated with shorter overall survival, while in non-HSCT patients, it also correlated with lower leukemia-free survival. Moreover, we provide a meta-analysis on the role of TP53 mutation in patients with chronic-phase Myelofibrosis, confirming its negative prognostic impact on overall survival. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/343757 2026-01-01T00:00:00Z https://hdl.handle.net/10807/343756 Titolo: Bioethics teaching in Italian Medical Degree Programs (MDP): an overview Autori: Refolo, Pietro; Raimondi, Costanza; Giardina, Simona; Masilla, Simone Salvatore; Todini, Clara; Oliva, Antonio; Spagnolo, Antonio Gioacchino Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/343756 2026-01-01T00:00:00Z https://hdl.handle.net/10807/343736 Titolo: ’Interculture postdigitali’ e ‘assemblaggi sociomateriali’: la ‘musica dei maranza’ tra agency, tecnologia e presa di parola Autori: Davide Zoletto; Stefano Pasta Abstract: La ricerca interculturale ha progressivamente superato letture meramente culturaliste per adottare approcci attenti alla complessità, all'intersezionalità e alla superdiversità. Questa prospettiva si è intrecciata con gli studi di media education, riconoscendo che la complessità socioculturale e linguistica si sviluppa in un ecosistema postdigitale e i processi di diversificazione, marginalizzazione ed emancipazione sono profondamente mediati dalle tecnologie. Da questo intreccio nasce il campo delle Interculture Postdigitali. Tale prospettiva dialoga in questo articolo con gli Science and Technology Studies (STS), che evidenziano il carattere coevolutivo delle relazioni tra innovazione tecnologica, contesti socioculturali ed educativi, mettendo in luce i margini di agency. In questo quadro, il saggio interpreta le forme contemporanee di soggettivazione giovanile attraverso il caso della cosiddetta "musica dei maranza", sviluppatasi nelle periferie urbane e caratterizzata da una forte presenza di giovani con background migratorio . Le pratiche musicali vengono analizzate come esito di specifici “assemblaggi sociomateriali” che intrecciano soggetti, piattaforme digitali, algoritmi, smartphone, software di produzione musicale e repertori culturali transnazionali. L'approccio proposto supera tanto il determinismo tecnologico quanto una lettura esclusivamente culturalista della trap, mostrando come la figura del maranza emerga quale soggettività situata e relazionale, prodotta dall'interazione tra pratiche culturali, infrastrutture digitali e dinamiche di riconoscimento e stigmatizzazione. Abstract: Intercultural research has progressively moved beyond purely culturalist interpretations, adopting approaches that are more attentive to complexity, intersectionality, and superdiversity. This perspective has increasingly intersected with media education studies, recognizing that sociocultural and linguistic complexity develops within a postdigital ecosystem, where processes of diversification, marginalization, and emancipation are deeply mediated by technologies. From this convergence emerges the field of Postdigital Intercultures. In this article, this perspective is brought into dialogue with Science and Technology Studies (STS), which emphasize the co-evolutionary character of the relationships between technological innovation and sociocultural and educational contexts, while highlighting the spaces for human agency. Within this framework, the article interprets contemporary forms of youth subjectivation through the case of the so-called maranza music, which has developed in urban peripheries and is characterized by the strong presence of young people with migrant backgrounds. These musical practices are analysed as the outcome of specific sociomaterial assemblages that bring together individuals, digital platforms, algorithms, smartphones, music production software, and transnational cultural repertoires. The proposed approach moves beyond both technological determinism and exclusively culturalist interpretations of trap music, showing how the figure of the maranza emerges as a situated and relational subjectivity produced through the interaction of cultural practices, digital infrastructures, and dynamics of recognition and stigmatization. Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/343736 2026-01-01T00:00:00Z https://hdl.handle.net/10807/343717 Titolo: Cultura afrodescendiente y espiritualidad: la sanación en la cultura garífuna Autori: Carini, Sara Thu, 01 Jan 2026 00:00:00 GMT https://hdl.handle.net/10807/343717 2026-01-01T00:00:00Z