https://hdl.handle.net/10807/1 2026-09-21T07:44:54Z 2026-09-21T07:44:54Z https://hdl.handle.net/10807/346937 2026-09-21T07:19:44Z 2026-01-01T00:00:00Z

Titolo: Moral foundations and volunteers’ trust in institutions and organisations during social crises: evidence from Poland and Italy Autori: Nowakowska, Iwona; Pozzi, Maura Abstract: In the present study, conducted in October 2023 in Poland and Italy, we examined a sample of volunteers (N = 518) about which moral foundations are associated with trust in specific organisations that played a significant role during recent social crises in Europe: the COVID-19 pandemic and the refugee crisis. The objects of trust included: (1) government; (2) public institutions; (3) non-governmental organisations; (4) self-help groups existent before the crises; and (5) self- help groups emergent in response to the crises. Individualising moral foundations were positively related to trust in non-governmental organisations and self-help entities, whereas binding moral foundations were positively associated with trust in government, public institutions and NGOs, as well as in self-help groups. We discuss these results in light of moral foundations theory and put forward suggestions for future research on how to effectively engage audiences with individualising- or binding-oriented moral profiles during social crises.

2026-01-01T00:00:00Z https://hdl.handle.net/10807/346936 2026-09-21T07:07:52Z 2026-01-01T00:00:00Z

Titolo: Biliverdin reductase A deficiency reveals sex- and brain region-specific vulnerability to high-fat diet feeding Autori: Lanzillotta, Simona; Sommella, Valeria; Zulli, Barbara; Picca, Anna; Calvani, Riccardo; Pagnotta, Sara; Paolozzi, Gabriele; Charlier, Mathilde; Marzetti, Emanuele; Cimini, Flavia Agata; Cavallo, Maria Gisella; Paul, Bindu D.; Butterfield, D. Allan; Di Domenico, Fabio; Perluigi, Marzia; Tramutola, Antonella; Barone, Eugenio

2026-01-01T00:00:00Z https://hdl.handle.net/10807/346916 2026-09-21T07:06:54Z 2025-01-01T00:00:00Z

Titolo: DPYD-Guided Dosing of Metronomic Capecitabine Plus Vinorelbine in Metastatic Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer: A Real-World Retrospective Study Autori: Francesco Schettini; Alexandro Membrino; Giuseppe Di Grazia; Aldo Caltavituro; Carla Strina; Manuela Milani; Antonina Impeduglia; Leda Paganini; Anna Bosi; Sara Tedoldi; Marta Gatti; Valeria Cervoni; Marzia Alberio; Mario Giuliano; Sergio Venturini; Daniele Generali Abstract: Purpose Metronomic chemotherapy with oral capecitabine + vinorelbine (Cape + VNL) provides synergistic cytostatic activity and antiangiogenic and immunomodulatory effects, potentially offering prolonged disease control with limited toxicity in HER2-negative metastatic breast cancer (MBC). However, efficacy in the real-world (RW) setting, especially in late lines, and the impact of dihydropyrimidine dehydrogenase (DPYD) polymorphisms on dose reduction and safety remain limited. Methods In this retrospective study, 200 patients with human epidermal growth factor receptor 2 (HER2)–negative MBC were treated at the ASST Cremona Hospital (2015-2023) with metronomic Cape (1000 mg twice daily, in normal metabolizers; 500 mg twice daily, in DPYD variant carriers) + VNL (20 mg/day, once daily, 5-days-on/2-days-off). All patients underwent pretreatment DPYD genotyping and dose adjustment. Treatment was administered in the second-to-fourth setting. The primary end point was time-to-next treatment or death (TNTD); secondary end points included overall survival (OS), disease control rate (DCR) ≥24 weeks, overall response rate (ORR), safety, and genotype-toxicity correlations. Results The median age was 61 years, and DPYD variants were present in 14.5% of patients; 34%, 41%, and 25% received therapy as second-, third-, and fourth-line treatment. The median TNTD was 22.0 weeks, and the OS was 64.0 weeks. The DCR was 38.5%, and the ORR was 22.0%. Efficacy was comparable between DPYD variant carriers and normal metabolizers (all P values > .05). In later lines, Eastern Cooperative Oncology Group performance status 2 and >2 metastatic sites were independent negative prognostic factors (all values P < .05). Overall, 7.5% grade 3 toxicities occurred, especially in variant carriers without dose reduction and grade 4-5 events. Conclusion These RW data suggest that metronomic Cape + VNL may represent a clinically active and manageable option in heavily pretreated HER2-negative MBC. Our findings support prospective evaluation of DPYD-guided dose individualization as a strategy to optimize the benefit-risk balance of fluoropyrimidine-based metronomic regimens.

2025-01-01T00:00:00Z https://hdl.handle.net/10807/346897 2026-09-20T02:17:02Z 2026-01-01T00:00:00Z

Titolo: Il Welfare nella città glocale Autori: valerio corradi Abstract: La prospettiva glocal applicata al welfare, pur riconoscendo l’importanza storica e politica della dimensione dello Stato-nazione, da una parte apre lo sguardo sul ruolo degli attori trans-nazionali come le grandi aggregazioni e le organizzazioni internazionali (es. Unione Europea). Dall’altra parte essa consente di focalizzare l’attenzione sulla sperimentazione di forme decentralizzate, territoriali, “sartoriali” e flessibili di welfare. Assumendo come caso emblematico di studio il welfare urbano della città di Brescia, emergono diversi tratti riconducibili al glocalità soprattutto nella misura in cui si problematizza e implementa un approccio analitico che va dal livello micro al macro.

2026-01-01T00:00:00Z