Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular malformations. These patients are similar to LGMD2K but have earlier onset and more severe motor disability. The current findings expand the spectrum of POMT1-associated phenotypes. Copyright © 2006 by AAN Enterprises, Inc.
D'Amico, A., Tessa, A., Bruno, C., Petrini, S., Biancheri, R., Pane, M., Pedemonte, M., Ricci, E., Falace, A., Rossi, A., Mercuri, E. M., Santorelli, F. M., Bertini, E. S., Expanding the clinical spectrum of POMT1 phenotype, <<NEUROLOGY>>, 2006; 66 (10): 1564-1567. [doi:10.1212/01.wnl.0000216145.66476.36] [https://hdl.handle.net/10807/260319]
Expanding the clinical spectrum of POMT1 phenotype
Pane, Marika;Ricci, Enzo;Mercuri, Eugenio Maria;Bertini, Enrico Silvio
2006
Abstract
Mutations in POMT1 have been identified in Walker-Warburg syndrome and in patients with limb-girdle muscular dystrophy and mental retardation (LGMD2K). The authors report new POMT1 mutations in three unrelated children with severe motor impairment, leg hypertrophy, and mental retardation but without brain and ocular malformations. These patients are similar to LGMD2K but have earlier onset and more severe motor disability. The current findings expand the spectrum of POMT1-associated phenotypes. Copyright © 2006 by AAN Enterprises, Inc.
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