Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

Leoni, C., Onesimo, R., Giorgio, V., Diamanti, A., Giorgio, D., Martini, L., Rossodivita, A. N., Tartaglia, M., Zampino, G., Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure, <<THE JOURNAL OF PEDIATRICS>>, 2016; 170 (mar): 322-324. [doi:10.1016/j.jpeds.2015.11.076] [http://hdl.handle.net/10807/115194]

Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Leoni, Chiara;Onesimo, Roberta;Giorgio, Valentina;Martini, Lucilla;Rossodivita, Aurora Natalia;Zampino, Giuseppe
2016

Abstract

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.
2016
Inglese
Leoni, C., Onesimo, R., Giorgio, V., Diamanti, A., Giorgio, D., Martini, L., Rossodivita, A. N., Tartaglia, M., Zampino, G., Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure, <<THE JOURNAL OF PEDIATRICS>>, 2016; 170 (mar): 322-324. [doi:10.1016/j.jpeds.2015.11.076] [http://hdl.handle.net/10807/115194]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/115194
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