Encapsulating peritoneal sclerosis is a serious complication of peritoneal dialysis and can occur even after transplant. The gut is partially or totally enveloped by a thick fibrous membrane that leads to the formation of multiple sections containing intestinal loops contracted and reduced in volume. Exacerbation after renal transplantation is a very rare but sometimes dramatic condition. We report a patient who developed intestinal obstruction due to encapsulating peritoneal sclerosis 1 year after a deceased-donor kidney transplant. Treatment included laparotomy, small-bowel lengthening by release of adhesions, and high doses of corticosteroids. The patient received immunosuppressive therapy with a combination of low-dose cyclosporine, everolimus, and prednisone, unchanged except for a temporary steroid increase in the postoperative period. We report success with this combined surgical plus medical therapy, with no recurrence after 81 months of follow-up.

Romagnoli, J., Pedroso, J. A. R., Salerno, M. P., Favi, E., Spagnoletti, G., Citterio, F., Posttransplant encapsulating peritoneal sclerosis, long-term success with everolimus and low-dose CNI: a case report, <<TRANSPLANTATION PROCEEDINGS>>, 2014; 46 (7): 2368-2370. [doi:10.1016/j.transproceed.2014.07.060] [http://hdl.handle.net/10807/71569]

Posttransplant encapsulating peritoneal sclerosis, long-term success with everolimus and low-dose CNI: a case report

Romagnoli, Jacopo;Pedroso, José Alberto Rodrigues;Salerno, Maria Paola;Favi, Evaldo;Spagnoletti, Gionata;Citterio, Franco
2014

Abstract

Encapsulating peritoneal sclerosis is a serious complication of peritoneal dialysis and can occur even after transplant. The gut is partially or totally enveloped by a thick fibrous membrane that leads to the formation of multiple sections containing intestinal loops contracted and reduced in volume. Exacerbation after renal transplantation is a very rare but sometimes dramatic condition. We report a patient who developed intestinal obstruction due to encapsulating peritoneal sclerosis 1 year after a deceased-donor kidney transplant. Treatment included laparotomy, small-bowel lengthening by release of adhesions, and high doses of corticosteroids. The patient received immunosuppressive therapy with a combination of low-dose cyclosporine, everolimus, and prednisone, unchanged except for a temporary steroid increase in the postoperative period. We report success with this combined surgical plus medical therapy, with no recurrence after 81 months of follow-up.
Inglese
Romagnoli, J., Pedroso, J. A. R., Salerno, M. P., Favi, E., Spagnoletti, G., Citterio, F., Posttransplant encapsulating peritoneal sclerosis, long-term success with everolimus and low-dose CNI: a case report, <<TRANSPLANTATION PROCEEDINGS>>, 2014; 46 (7): 2368-2370. [doi:10.1016/j.transproceed.2014.07.060] [http://hdl.handle.net/10807/71569]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/71569
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
social impact