Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.

Marino, M., Scuderi, F., Samengo, D. M., Saltelli, G., Maiuri, M., Shen, C., Mei, L., Sabatelli, M., Pani, G., Antonini, G., Evoli, A., Bartoccioni, E., Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis, <<PLOS ONE>>, 2015; 10 (8): e0135378-e0135378. [doi:10.1371/journal.pone.0135378] [http://hdl.handle.net/10807/70194]

Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis

Marino, Mariapaola;Scuderi, Flavia;Samengo, Daniela Maria;Sabatelli, Mario;Pani, Giovambattista;Evoli, Amelia;Bartoccioni, Emanuela
2015

Abstract

Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.
Inglese
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135378
Marino, M., Scuderi, F., Samengo, D. M., Saltelli, G., Maiuri, M., Shen, C., Mei, L., Sabatelli, M., Pani, G., Antonini, G., Evoli, A., Bartoccioni, E., Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis, <>, 2015; 10 (8): e0135378-e0135378. [doi:10.1371/journal.pone.0135378] [http://hdl.handle.net/10807/70194]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/70194
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