Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.

Marino, M., Scuderi, F., Samengo, D. M., Saltelli, G., Maiuri, M., Shen, C., Mei, L., Sabatelli, M., Pani, G., Antonini, G., Evoli, A., Bartoccioni, E., Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis, <<PLOS ONE>>, 2015; 10 (8): e0135378-e0135378. [doi:10.1371/journal.pone.0135378] [http://hdl.handle.net/10807/70194]

Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis

Marino, Mariapaola;Scuderi, Flavia;Samengo, Daniela Maria;Sabatelli, Mario;Pani, Giovambattista;Evoli, Amelia;Bartoccioni, Emanuela
2015

Abstract

Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.
2015
Inglese
Marino, M., Scuderi, F., Samengo, D. M., Saltelli, G., Maiuri, M., Shen, C., Mei, L., Sabatelli, M., Pani, G., Antonini, G., Evoli, A., Bartoccioni, E., Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis, <<PLOS ONE>>, 2015; 10 (8): e0135378-e0135378. [doi:10.1371/journal.pone.0135378] [http://hdl.handle.net/10807/70194]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/70194
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 28
  • ???jsp.display-item.citation.isi??? 26
social impact