Pseudohypoparathyroidism type 1A and its association with bipolar disorder (BD) have never been reported so far. We report a new case with both clinical entities and discuss the potential pathophysiological mechanisms of this association (protein kinase A hypoactivation, parathyroid hormone, hypocalcemia, protein kinase C activation, vitamin D deficiency). In this patient, the correction of the underlying calcium and vitamin D deficiencies leads to a better BD outcome and lower dosage of psychopharmacological agents. The conclusions might be generalized for a better understanding and management of these conditions

Kadilli, I., Colicchio, S., Guglielmo, R., Vollono, C., Della Marca, G., Janiri, L., Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A, <<GENERAL HOSPITAL PSYCHIATRY>>, 2015; (Settembre): 497-497. [doi:10.1016/j.genhosppsych.2015.06.008] [http://hdl.handle.net/10807/67692]

Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A

Kadilli, Irket;Colicchio, Salvatore;Guglielmo, Riccardo;Vollono, Catello;Della Marca, Giacomo;Janiri, Luigi
2015

Abstract

Pseudohypoparathyroidism type 1A and its association with bipolar disorder (BD) have never been reported so far. We report a new case with both clinical entities and discuss the potential pathophysiological mechanisms of this association (protein kinase A hypoactivation, parathyroid hormone, hypocalcemia, protein kinase C activation, vitamin D deficiency). In this patient, the correction of the underlying calcium and vitamin D deficiencies leads to a better BD outcome and lower dosage of psychopharmacological agents. The conclusions might be generalized for a better understanding and management of these conditions
Inglese
Kadilli, I., Colicchio, S., Guglielmo, R., Vollono, C., Della Marca, G., Janiri, L., Clinical insights by the presence of bipolar disorder in pseudohypoparathyroidism type 1A, <<GENERAL HOSPITAL PSYCHIATRY>>, 2015; (Settembre): 497-497. [doi:10.1016/j.genhosppsych.2015.06.008] [http://hdl.handle.net/10807/67692]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/67692
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