Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.
Capalbo, A., Sagnella, F., Apa, R., Fulghesu, A., Lanzone, A., Morciano, A., Farcomeni, A., Gangale, M., Moro, F., Martinez, D., Ciardulli, A., Palla, C., Uras, M., Spettu, F., Cappai, A., Carcassi, C., Neri, G., Tiziano, F. D., The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population, <<CLINICAL ENDOCRINOLOGY>>, 2012; 77 (1): 113-119. [doi:10.1111/j.1365-2265.2012.04372.x]
The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population
Capalbo, Antonio;Sagnella, Francesca;Apa, Rosanna;Lanzone, Antonio;Morciano, Andrea;Moro, Francesca;Martinez, Daniela;Neri, Giovanni;Tiziano, Francesco Danilo
2012
Abstract
Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.
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