The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.

Rigante, D., Inzitari, R., Carone, M., Fanali, C., Stabile, A., Cabras, T., Capoluongo, E. D., Gaspari, S., Barone, G., Castagnola, M., Correspondence between clinical improvement and proteomic changes of the salivary peptide complex ina child with primary Sjogren syndrome, <<RHEUMATOLOGY INTERNATIONAL>>, 2008; 2008 (Giugno): 801-806 [http://hdl.handle.net/10807/3675]

Correspondence between clinical improvement and proteomic changes of the salivary peptide complex ina child with primary Sjogren syndrome

Rigante;Donato; Inzitari;M.; Fanali;Chiara; Stabile;Achille; Cabras;Tiziana; Capoluongo;S.; Barone;Giuseppe; Castagnola
2008

Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient's salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.
Inglese
Rigante, D., Inzitari, R., Carone, M., Fanali, C., Stabile, A., Cabras, T., Capoluongo, E. D., Gaspari, S., Barone, G., Castagnola, M., Correspondence between clinical improvement and proteomic changes of the salivary peptide complex ina child with primary Sjogren syndrome, <<RHEUMATOLOGY INTERNATIONAL>>, 2008; 2008 (Giugno): 801-806 [http://hdl.handle.net/10807/3675]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/3675
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact