CANOMAD (chronic ataxic neuropathy, opthalmoplegia, IgM paraprotein, cold agglutinins and disialosyl antibodies) is a rare variant of IgM paraproteinaemic neuropathy in which the paraprotein fraction contains antibodies against specific disialylated gangliosides, including GD1B, GD3, GT1B and GQ1B [1]. This disorder has so far not been reported in association with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Here we describe a patient who developed SIADH during the first relapse of CANOMAD
Iorio, R., Capone, F., Iannaccone, E., Willison, H., Modoni, A., Tonali, P. A., Silvestri, G., SIADH in a patient with sensory ataxic neuropathy with anti-disialosyl antibodies (CANOMAD), <<JOURNAL OF NEUROLOGY>>, 2009; (Luglio): 1177-1179 [http://hdl.handle.net/10807/31878]
SIADH in a patient with sensory ataxic neuropathy with anti-disialosyl antibodies (CANOMAD)
Iorio, Raffaele;Capone, Fioravante;Iannaccone, Elisabetta;Modoni, Anna;Tonali, Pietro Attilio;Silvestri, Gabriella
2009
Abstract
CANOMAD (chronic ataxic neuropathy, opthalmoplegia, IgM paraprotein, cold agglutinins and disialosyl antibodies) is a rare variant of IgM paraproteinaemic neuropathy in which the paraprotein fraction contains antibodies against specific disialylated gangliosides, including GD1B, GD3, GT1B and GQ1B [1]. This disorder has so far not been reported in association with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Here we describe a patient who developed SIADH during the first relapse of CANOMAD
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