Purpose: In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods: We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results: 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28. Conclusions: HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes.

Tabah, A., Buetti, N., Staiquly, Q., Ruckly, S., Akova, M., Abdullah Tarik Aslan,, Leone, M., Andrew Conway Morris,, Bassetti, M., Arvaniti, K., Lipman, J., Ferrer, R., Qiu, H., Paiva, J., Povoa, P., Liesbet De Bus,, Jan De Waele,, Zand, F., Gurjar, M., Alsis, A., Abidi, K., Bracht, H., Hayashi, Y., Jeon, K., Elhadi, M., Barbier, F., Timsit, J., Tabah, A., Pollock, H., Margetts, B., Young, M., Bhadange, N., Tyler, S., Ledtischke, A., Finnis, M., Ledtischke, A., Finnis, M., Dwivedi, J., Saxena, M., Biradar, V., Soar, N., Sarode, V., Brewster, D., Regli, A., Weeda, E., Ahmed, S., Fourie, C., Laupland, K., Ramanan, M., Walsham, J., Meyer, J., Litton, E., Anna Maria Palermo,, Yap, T., Eroglu, E., Antony George Attokaran,, Jaramillo, C., Khalid Mahmood Khan Nafees,, Nurhikmahtul Aqilah Haji Abd Rashid,, Haji Adi Muhamad Ibnu Walid,, Mon, T., Dhakshina Moorthi, P., Sudhirchandra, S., Dhadappa Damodar Sridharan,, Haibo, Q., Jianfeng, X., Wei-Hua, L., Zhen, W., Qian, C., Luo, J., Chen, X., Wang, H., Zhao, P., Zhao, J., Wusi, Q., Mingmin, C., Lei, X., Yin, C., Wang, R., Wang, J., Yin, Y., Zhang, M., Jilu, Y., Chungfang, H., Zhou, S., Huang, M., Yan, J., Wang, Y., Qin, B., Ling, Y., Weifeng, X., Peije, L., Geng, N., Hayashi, Y., Karumai, T., Yamasaki, M., Hashimoto, S., Hosokawa, K., Makino, J., Matsuyoshi, T., Kuriyama, A., Shigemitsu, H., Mishima, Y., Nagashima, M., Yoshida, H., Fujitani, S., Omori, K., Rinka, H., Saito, H., Atobe, K., Kato, H., Takaki, S., Shahnaz Hasan, M., Muhamad Fadhil Hadi Jamaluddin,, Lee See Pheng,, Visvalingam, S., Mun Thing Liew,, Siong Ling Danny Wong,, Kean Khang Fong,, Hamizah Bt Abdul Rahman,, Zuraini Md Noor,, Lee Kok Tong,, Hamid Azman, A., Mohd Zulfakar Mazlan,, Ali, S., Jeon, K., Lee, S., Park, S., Seung Yong Park,, Sung Yoon Lim,, Qing Yuan Goh,, Shin Yi Ng,, Sui An Lie,, Andrea Lay Hoon Kwa,, Ken Junyang Goh,, Andrew Yunkai Li,, Caroline Yu Ming Ong,, Jia Yan Lim,, Jessica Lishan Quah,, Kangqi, N., Louis Xiang Long Ng,, Yu Chang Yeh,, Chou, N., Cia, C., Ting-Yu, H., Kuo, L., Shih-Chi, K., Wongsurakiat, P., Apichatbutr, Y., Chiewroongroj, S., Nadeem, R., Ashraf El Houfi,, Alsisi, A., Elhadidy, A., Barsoum, M., Osman, N., Mostafa, T., Elbahnasawy, M., Saber, A., Aldhalia, A., Elmandouh, O., Elsayed, A., Elbadawy, M. A., Awad, A. K., Hemead, H. M., Zand, F., Ouhadian, M., Seyed Hamid Borsi,, Mehraban, Z., Kashipazha, D., Ahmadi, F., Savaie, M., Soltani, F., Rashidi, M., Baghbanian, R., Javaherforoosh, F., Amiri, F., Kiani, A., Mohammad Amin Zargar,, Mahmoodpoor, A., Aalinezhad, F., Dabiri, G., Sabetian, G., Sarshad, H., Masjedi, M., Tajvidi, R., Seyed Mohammad Nasirodin Tabatabaei,, Abdullah Khudhur Ahmed,, Singer, P., Kagan, I., Rigler, M., Belman, D., Levin, P., Harara, B., Diab, A., Abilama, F., Ibrahim, R., Fares, A., Buimsaedah, A., Gamra, M., Aqeelah, A., Almajdoub Mohammed Aliali,, Ahmed Gaber Sadik Homaidan,, Almiqlash, B., Bilkhayr, H., Bouhuwaish, A., Ahmed Sa Taher,, Abdulwahed, E., Abousnina, F. A., Aisha Khaled Hdada,, Jobran, R., Hayat Ben Hasan,, Rabab Shaban Ben Hasan,, Serghini, I., Seddiki, R., Boukatta, B., Kanjaa, N., Mouhssine, D., Maazouzi Ahmed Wajdi,, Dendane, T., Amine Ali Zeggwagh,, Housni, B., Younes, O., Hachimi, A., Ghannam, A., Belkhadir, Z., Amro, S., Mustafa Abu Jayyab,, Ali Ait Hssain,, Elbuzidi, A., Karic, E., Lance, M., Nissar, S., Sallam, H., Elrabi, O., Almekhlafi, G. A., Awad, M., Aljabbary, A., Mohammad Karam Chaaban,, Abu-Sayf, N., Al-Jadaan, M., Bakr, L., Bouaziz, M., Turki, O., Sellami, W., Centeno, P., Lic Natalia Morvillo,, José Oscar Acevedo,, Patricia Mabel Lopez,, Fernández, R., Segura, M., Dra Marta Aparicio,, Microbiologa Irene Alonzo,, Nuccetelli, Y., Montefiore, P., Luis Felipe Reyes,, Luis Felipe Reyes,, Ñamendys-Silva, S. A., Romero-Gonzalez, J. P., Hermosillo, M., Roberto Alejandro Castillo,, Jesús Nicolás Pantoja Leal,, Candy Garcia Aguilar,, Mara Ocotlan Gonzalez Herrera,, Missael Vladimir Espinoza Villafuerte,, Lomeli-Teran, M., Dominguez-Cherit, J. G., Davalos-Alvarez, A., Ñamendys-Silva, S. A., Sánchez-Hurtado, L., Tejeda-Huezo, B., Perez-Nieto, O. R., Ernesto Deloya Tomas,, Liesbet De Bus,, Jan De Waele,, Hollevoet, I., Denys, W., Bourgeois, M., Vanderhaeghen, S. F. M., Mesland, J., Henin, P., Haentjens, L., Biston, P., Noel, C., Layos, N., Misset, B., Nicolas De Schryver,, Serck, N., Wittebole, X., Elisabeth De Waele,, Opdenacker, G., Kovacevic, P., Zlojutro, B., Custovic, A., Filipovic-Grcic, I., Radonic, R., Ana Vujaklija Brajkovic,, Persec, J., Sakan, S., Nikolic, M., Lasic, H., Leone, M., Arbelot, C., Timsit, J., Patrier, J., Zappela, N., Montravers, P., Dulac, T., Castanera, J., Auchabie, J., Anthony Le Meur,, Marchalot, A., Beuzelin, M., Massri, A., Guesdon, C., Escudier, E., Mateu, P., Rosman, J., Leroy, O., Alfandari, S., Nica, A., Souweine, B., Coupez, E., Duburcq, T., Kipnis, E., Bortolotti, P., Mathieu Le Souhaitier,, Mira, J., Garcon, P., Duprey, M., Thyrault, M., Paulet, R., Philippart, F., Tran, M., Bruel, C., Weiss, E., Janny, S., Foucrier, A., Perrigault, P., Djanikian, F., Barbier, F., Gainnier, M., Bourenne, J., Louis, G., Smonig, R., Argaud, L., Baudry, T., Armand Mekonted Dessap,, Razazi, K., Kalfon, P., Badre, G., Larcher, R., Lefrant, J., Roger, C., Sarton, B., Silva, S., Demeret, S., Loïc Le Guennec,, Siami, S., Aparicio, C., Voiriot, G., Fartoukh, M., Dahyot-Fizelier, C., Imzi, N., Klouche, K., Bracht, H., Hoheisen, S., Bloos, F., Thomas-Rueddel, D., Petros, S., Pasieka, B., Dubler, S., Schmidt, K., Gottschalk, A., Wempe, C., Lepper, P., Metz, C., Viderman, D., Ymbetzhanov, Y., Mugazov, M., Bazhykayeva, Y., Kaligozhin, Z., Babashev, B., Merenkov, Y., Temirov, T., Arvaniti, K., Smyrniotis, D., Psallida, V., Fildisis, G., Soulountsi, V., Kaimakamis, E., Iasonidou, C., Papoti, S., Renta, F., Vasileiou, M., Romanou, V., Koutsoukou, V., Mariana Kristina Matei,, Moldovan, L., Karaiskos, I., Paskalis, H., Marmanidou, K., Papanikolaou, M., Kampolis, C., Oikonomou, M., Kogkopoulos, E., Nikolaou, C., Sakkalis, A., Chatzis, M., Georgopoulou, M., Efthymiou, A., Chantziara, V., Sakagianni, A., Athanasa, Z., Papageorgiou, E., Ali, F., Dimopoulos, G., Mariota Panagiota Almiroudi,, Malliotakis, P., Marouli, D., Theodorou, V., Retselas, I., Kouroulas, V., Papathanakos, G., Montrucchio, G., Sales, G., Gennaro,, De Pascale, G., Montini, L., Carelli, S., Vargas, J., Valentina Di Gravio,, Daniele Roberto Giacobbe,, Gratarola, A., Porcile, E., Mirabella, M., Daroui, I., Lodi, G., Zuccaro, F., Maria Grazia Schlevenin,, Pelosi, P., Battaglini, D., Cortegiani, A., Ippolito, M., Bellina, D., Andrea Di Guardo,, Pelagalli, L., Covotta, M., Rocco, M., Fiorelli, S., Cotoia, A., Anna Chiara Rizzo,, Mikstacki, A., Tamowicz, B., Irmina Kaptur Komorowska,, Szczesniak, A., Bojko, J., Kotkowska, A., Walczak-Wieteska, P., Wasowska, D., Nowakowski, T., Broda, H., Peichota, M., Pietraszek-Grzywaczewska, I., Martin-Loeches, I., Bisanti, A., Cartoze, N., Pereira, T., Guimarães, N., Alves, M., Ana Josefina Pinheiro Marques,, Ana Rios Pinto,, Krystopchuk, A., Teresa, A., António Manuel Pereira De Figueiredo,, Botelho, I., Duarte, T., Costa, V., Rui Pedro Cunha,, Molinos, E., Tito Da Costa,, Ledo, S., Queiró, J., Pascoalinho, D., Nunes, C., José Pedro Moura,, Pereira, É., António Carvalho Mendes,, Valeanu, L., Bubenek-Turconi, S., Ioana Marina Grintescu,, Cobilinschi, C., Daniela Carmen Filipescu,, Cornelia Elena Predoi,, Tomescu, D., Popescu, M., Marcu, A., Grigoras, I., Lungu, O., Gritsan, A., Anderzhanova, A., Meleshkina, Y., Magomedov, M., Zubareva, N., Tribulev, M., Gaigolnik, D., Eremenko, A., Vistovskaya, N., Chukina, M., Belskiy, V., Furman, M., Ricard Ferrer Rocca,, Martinez, M., Casares, V., Vera, P., Flores, M., Joaquin Amador Amerigo,, Maria Pilar Gracia Arnillas,, Rosana Munoz Bermudez,, Armestar, F., Catalan, B., Roig, R., Raguer, L., María Dolores Quesada,, Emilio Diaz Santos,, Gomà, G., Ubeda, A., Dra Maria Salgado,, Lorena Forcelledo Espina,, Emilio Garcia Prieto,, Dra Mj Asensio,, Rodriguez, D. M., Maseda, E., Alejandro Suarez De La Rica,, Ignacio Ayestaran, J., Novo, M., Miguel Angel Blasco-Navalpotro,, Alberto Orejas Gallego,, Sjövall, F., Spahic, D., Carl Johan Svensson,, Haney, M., Edin, A., Åkerlund, J., Lina De Geer,, Prazak, J., Jakob, S., Pagani, J., Abed-Maillard, S., Akova, M., Abdullah Tarik Aslan,, Timuroglu, A., Kocagoz, S., Kusoglu, H., Mehtap, S., Ceyhun, S., Neriman Defne Altintas,, Talan, L., Kayaaslan, B., Ayşe Kaya Kalem,, Kurt, I., Telli, M., Ozturk, B., Erol, Ç., Emine Kubra Dindar Demiray,, Çolak, S., Akbas, T., Gundogan, K., Sari, A., Agalar, C., Çolak, O., Baykam, N. N., Akdogan, O. O., Yilmaz, M., Tunay, B., Cakmak, R., Saltoglu, N., Karaali, R., Koksal, I., Aksoy, F., Eroglu, A., Kemal Tolga Saracoglu,, Bilir, Y., Guzeldag, S., Ersoz, G., Evik, G., Sungurtekin, H., Ozgen, C., Erdoğan, C., Gürbüz, Y., Altin, N., Bayindir, Y., Ersoy, Y., Goksu, S., Akyol, A., Batirel, A., Sabahat Cagan Aktas,, Andrew Conway Morris,, Routledge, M., Andrew Conway Morris,, Ercole, A., Antcliffe, D., Rojo, R., Tizard, K., Faulkner, M., Cowton, A., Kent, M., Raj, A., Zormpa, A., Tinaslanidis, G., Khade, R., Torlinski, T., Mulhi, R., Goyal, S., Bajaj, M., Soltan, M., Yonan, A., Dolan, R., Johnson, A., Macfie, C., Lennard, J., Templeton, M., Sonia Sousa Arias,, Franke, U., Hugill, K., Angell, H., Parcell, B. J., Cobb, K., Cole, S., Smith, T., Graham, C., Cerman, J., Keegan, A., Ritzema, J., Sanderson, A., Roshdy, A., Szakmany, T., Baumer, T., Longbottom, R., Hall, D., Tatham, K., Loftus, S., Husain, A., Black, E., Jhanji, S., Rao Baikady, R., Mcguigan, P., Mckee, R., Kannan, S., Antrolikar, S., Marsden, N., Valentina Della Torre,, Banach, D., Zaki, A., Jackson, M., Chikungwa, M., Attwood, B., Patel, J., Tilley, R. E., Humphreys, M. S. K., Paul Jean Renaud,, Sokhan, A., Burma, Y., Sligl, W., Baig, N., Mccoshen, L., Kutsogiannis, D. J., Sligl, W., Thompson, P., Hewer, T., Rabbani, R., Shihan Mahmud Redwanul Huq,, Hasan, R., Mohammad Motiul Islam,, Gurjar, M., Baronia, A., Kothari, N., Sharma, A., Karmakar, S., Sharma, P., Nimbolkar, J., Samdani, P., Vaidyanathan, R., Noor Ahmedi Rubina,, Jain, N., Pahuja, M., Singh, R., Shekhar, S., Syed Nabeel Muzaffar,, Ozair, A., Suhail Sarwar Siddiqui,, Bose, P., Datta, A., Rathod, D., Patel, M., Renuka, M. K., Baby, S. K., Dsilva, C., Chandran, J., Ghosh, P., Mukherjee, S., Sheshala, K., Krushna Chandra Misra,, Saidu Yusuf Yakubu,, Euphemia Mgbosoro Ugwu,, Olatosi, J. O., Desalu, I., Asiyanbi, G., Oladimeji, M., Idowu, O., Adeola, F., Melanie Mc Cree,, Ali Adil Ali Karar,, Elfayadh Saidahmed &am, E. S. &., ,, Hamid, H. K. S., Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study, <<INTENSIVE CARE MEDICINE>>, 2023; 49 (2): 178-190. [doi:10.1007/s00134-022-06944-2] [https://hdl.handle.net/10807/304060]

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study

De Pascale, Gennaro;Montini, Luca;
2023

Abstract

Purpose: In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for optimizing management, and developing guidelines and clinical trials. Methods: We carried out a prospective international cohort study of adult patients (≥ 18 years of age) with HA-BSI treated in intensive care units (ICUs) between June 2019 and February 2021. Results: 2600 patients from 333 ICUs in 52 countries were included. 78% HA-BSI were ICU-acquired. Median Sequential Organ Failure Assessment (SOFA) score was 8 [IQR 5; 11] at HA-BSI diagnosis. Most frequent sources of infection included pneumonia (26.7%) and intravascular catheters (26.4%). Most frequent pathogens were Gram-negative bacteria (59.0%), predominantly Klebsiella spp. (27.9%), Acinetobacter spp. (20.3%), Escherichia coli (15.8%), and Pseudomonas spp. (14.3%). Carbapenem resistance was present in 37.8%, 84.6%, 7.4%, and 33.2%, respectively. Difficult-to-treat resistance (DTR) was present in 23.5% and pan-drug resistance in 1.5%. Antimicrobial therapy was deemed adequate within 24 h for 51.5%. Antimicrobial resistance was associated with longer delays to adequate antimicrobial therapy. Source control was needed in 52.5% but not achieved in 18.2%. Mortality was 37.1%, and only 16.1% had been discharged alive from hospital by day-28. Conclusions: HA-BSI was frequently caused by Gram-negative, carbapenem-resistant and DTR pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy. Mortality was high, and at day-28 only a minority of the patients were discharged alive from the hospital. Prevention of antimicrobial resistance and focusing on adequate antimicrobial therapy and source control are important to optimize patient management and outcomes.
2023
Inglese
Tabah, A., Buetti, N., Staiquly, Q., Ruckly, S., Akova, M., Abdullah Tarik Aslan,, Leone, M., Andrew Conway Morris,, Bassetti, M., Arvaniti, K., Lipman, J., Ferrer, R., Qiu, H., Paiva, J., Povoa, P., Liesbet De Bus,, Jan De Waele,, Zand, F., Gurjar, M., Alsis, A., Abidi, K., Bracht, H., Hayashi, Y., Jeon, K., Elhadi, M., Barbier, F., Timsit, J., Tabah, A., Pollock, H., Margetts, B., Young, M., Bhadange, N., Tyler, S., Ledtischke, A., Finnis, M., Ledtischke, A., Finnis, M., Dwivedi, J., Saxena, M., Biradar, V., Soar, N., Sarode, V., Brewster, D., Regli, A., Weeda, E., Ahmed, S., Fourie, C., Laupland, K., Ramanan, M., Walsham, J., Meyer, J., Litton, E., Anna Maria Palermo,, Yap, T., Eroglu, E., Antony George Attokaran,, Jaramillo, C., Khalid Mahmood Khan Nafees,, Nurhikmahtul Aqilah Haji Abd Rashid,, Haji Adi Muhamad Ibnu Walid,, Mon, T., Dhakshina Moorthi, P., Sudhirchandra, S., Dhadappa Damodar Sridharan,, Haibo, Q., Jianfeng, X., Wei-Hua, L., Zhen, W., Qian, C., Luo, J., Chen, X., Wang, H., Zhao, P., Zhao, J., Wusi, Q., Mingmin, C., Lei, X., Yin, C., Wang, R., Wang, J., Yin, Y., Zhang, M., Jilu, Y., Chungfang, H., Zhou, S., Huang, M., Yan, J., Wang, Y., Qin, B., Ling, Y., Weifeng, X., Peije, L., Geng, N., Hayashi, Y., Karumai, T., Yamasaki, M., Hashimoto, S., Hosokawa, K., Makino, J., Matsuyoshi, T., Kuriyama, A., Shigemitsu, H., Mishima, Y., Nagashima, M., Yoshida, H., Fujitani, S., Omori, K., Rinka, H., Saito, H., Atobe, K., Kato, H., Takaki, S., Shahnaz Hasan, M., Muhamad Fadhil Hadi Jamaluddin,, Lee See Pheng,, Visvalingam, S., Mun Thing Liew,, Siong Ling Danny Wong,, Kean Khang Fong,, Hamizah Bt Abdul Rahman,, Zuraini Md Noor,, Lee Kok Tong,, Hamid Azman, A., Mohd Zulfakar Mazlan,, Ali, S., Jeon, K., Lee, S., Park, S., Seung Yong Park,, Sung Yoon Lim,, Qing Yuan Goh,, Shin Yi Ng,, Sui An Lie,, Andrea Lay Hoon Kwa,, Ken Junyang Goh,, Andrew Yunkai Li,, Caroline Yu Ming Ong,, Jia Yan Lim,, Jessica Lishan Quah,, Kangqi, N., Louis Xiang Long Ng,, Yu Chang Yeh,, Chou, N., Cia, C., Ting-Yu, H., Kuo, L., Shih-Chi, K., Wongsurakiat, P., Apichatbutr, Y., Chiewroongroj, S., Nadeem, R., Ashraf El Houfi,, Alsisi, A., Elhadidy, A., Barsoum, M., Osman, N., Mostafa, T., Elbahnasawy, M., Saber, A., Aldhalia, A., Elmandouh, O., Elsayed, A., Elbadawy, M. A., Awad, A. K., Hemead, H. M., Zand, F., Ouhadian, M., Seyed Hamid Borsi,, Mehraban, Z., Kashipazha, D., Ahmadi, F., Savaie, M., Soltani, F., Rashidi, M., Baghbanian, R., Javaherforoosh, F., Amiri, F., Kiani, A., Mohammad Amin Zargar,, Mahmoodpoor, A., Aalinezhad, F., Dabiri, G., Sabetian, G., Sarshad, H., Masjedi, M., Tajvidi, R., Seyed Mohammad Nasirodin Tabatabaei,, Abdullah Khudhur Ahmed,, Singer, P., Kagan, I., Rigler, M., Belman, D., Levin, P., Harara, B., Diab, A., Abilama, F., Ibrahim, R., Fares, A., Buimsaedah, A., Gamra, M., Aqeelah, A., Almajdoub Mohammed Aliali,, Ahmed Gaber Sadik Homaidan,, Almiqlash, B., Bilkhayr, H., Bouhuwaish, A., Ahmed Sa Taher,, Abdulwahed, E., Abousnina, F. A., Aisha Khaled Hdada,, Jobran, R., Hayat Ben Hasan,, Rabab Shaban Ben Hasan,, Serghini, I., Seddiki, R., Boukatta, B., Kanjaa, N., Mouhssine, D., Maazouzi Ahmed Wajdi,, Dendane, T., Amine Ali Zeggwagh,, Housni, B., Younes, O., Hachimi, A., Ghannam, A., Belkhadir, Z., Amro, S., Mustafa Abu Jayyab,, Ali Ait Hssain,, Elbuzidi, A., Karic, E., Lance, M., Nissar, S., Sallam, H., Elrabi, O., Almekhlafi, G. A., Awad, M., Aljabbary, A., Mohammad Karam Chaaban,, Abu-Sayf, N., Al-Jadaan, M., Bakr, L., Bouaziz, M., Turki, O., Sellami, W., Centeno, P., Lic Natalia Morvillo,, José Oscar Acevedo,, Patricia Mabel Lopez,, Fernández, R., Segura, M., Dra Marta Aparicio,, Microbiologa Irene Alonzo,, Nuccetelli, Y., Montefiore, P., Luis Felipe Reyes,, Luis Felipe Reyes,, Ñamendys-Silva, S. A., Romero-Gonzalez, J. P., Hermosillo, M., Roberto Alejandro Castillo,, Jesús Nicolás Pantoja Leal,, Candy Garcia Aguilar,, Mara Ocotlan Gonzalez Herrera,, Missael Vladimir Espinoza Villafuerte,, Lomeli-Teran, M., Dominguez-Cherit, J. G., Davalos-Alvarez, A., Ñamendys-Silva, S. A., Sánchez-Hurtado, L., Tejeda-Huezo, B., Perez-Nieto, O. R., Ernesto Deloya Tomas,, Liesbet De Bus,, Jan De Waele,, Hollevoet, I., Denys, W., Bourgeois, M., Vanderhaeghen, S. F. M., Mesland, J., Henin, P., Haentjens, L., Biston, P., Noel, C., Layos, N., Misset, B., Nicolas De Schryver,, Serck, N., Wittebole, X., Elisabeth De Waele,, Opdenacker, G., Kovacevic, P., Zlojutro, B., Custovic, A., Filipovic-Grcic, I., Radonic, R., Ana Vujaklija Brajkovic,, Persec, J., Sakan, S., Nikolic, M., Lasic, H., Leone, M., Arbelot, C., Timsit, J., Patrier, J., Zappela, N., Montravers, P., Dulac, T., Castanera, J., Auchabie, J., Anthony Le Meur,, Marchalot, A., Beuzelin, M., Massri, A., Guesdon, C., Escudier, E., Mateu, P., Rosman, J., Leroy, O., Alfandari, S., Nica, A., Souweine, B., Coupez, E., Duburcq, T., Kipnis, E., Bortolotti, P., Mathieu Le Souhaitier,, Mira, J., Garcon, P., Duprey, M., Thyrault, M., Paulet, R., Philippart, F., Tran, M., Bruel, C., Weiss, E., Janny, S., Foucrier, A., Perrigault, P., Djanikian, F., Barbier, F., Gainnier, M., Bourenne, J., Louis, G., Smonig, R., Argaud, L., Baudry, T., Armand Mekonted Dessap,, Razazi, K., Kalfon, P., Badre, G., Larcher, R., Lefrant, J., Roger, C., Sarton, B., Silva, S., Demeret, S., Loïc Le Guennec,, Siami, S., Aparicio, C., Voiriot, G., Fartoukh, M., Dahyot-Fizelier, C., Imzi, N., Klouche, K., Bracht, H., Hoheisen, S., Bloos, F., Thomas-Rueddel, D., Petros, S., Pasieka, B., Dubler, S., Schmidt, K., Gottschalk, A., Wempe, C., Lepper, P., Metz, C., Viderman, D., Ymbetzhanov, Y., Mugazov, M., Bazhykayeva, Y., Kaligozhin, Z., Babashev, B., Merenkov, Y., Temirov, T., Arvaniti, K., Smyrniotis, D., Psallida, V., Fildisis, G., Soulountsi, V., Kaimakamis, E., Iasonidou, C., Papoti, S., Renta, F., Vasileiou, M., Romanou, V., Koutsoukou, V., Mariana Kristina Matei,, Moldovan, L., Karaiskos, I., Paskalis, H., Marmanidou, K., Papanikolaou, M., Kampolis, C., Oikonomou, M., Kogkopoulos, E., Nikolaou, C., Sakkalis, A., Chatzis, M., Georgopoulou, M., Efthymiou, A., Chantziara, V., Sakagianni, A., Athanasa, Z., Papageorgiou, E., Ali, F., Dimopoulos, G., Mariota Panagiota Almiroudi,, Malliotakis, P., Marouli, D., Theodorou, V., Retselas, I., Kouroulas, V., Papathanakos, G., Montrucchio, G., Sales, G., Gennaro,, De Pascale, G., Montini, L., Carelli, S., Vargas, J., Valentina Di Gravio,, Daniele Roberto Giacobbe,, Gratarola, A., Porcile, E., Mirabella, M., Daroui, I., Lodi, G., Zuccaro, F., Maria Grazia Schlevenin,, Pelosi, P., Battaglini, D., Cortegiani, A., Ippolito, M., Bellina, D., Andrea Di Guardo,, Pelagalli, L., Covotta, M., Rocco, M., Fiorelli, S., Cotoia, A., Anna Chiara Rizzo,, Mikstacki, A., Tamowicz, B., Irmina Kaptur Komorowska,, Szczesniak, A., Bojko, J., Kotkowska, A., Walczak-Wieteska, P., Wasowska, D., Nowakowski, T., Broda, H., Peichota, M., Pietraszek-Grzywaczewska, I., Martin-Loeches, I., Bisanti, A., Cartoze, N., Pereira, T., Guimarães, N., Alves, M., Ana Josefina Pinheiro Marques,, Ana Rios Pinto,, Krystopchuk, A., Teresa, A., António Manuel Pereira De Figueiredo,, Botelho, I., Duarte, T., Costa, V., Rui Pedro Cunha,, Molinos, E., Tito Da Costa,, Ledo, S., Queiró, J., Pascoalinho, D., Nunes, C., José Pedro Moura,, Pereira, É., António Carvalho Mendes,, Valeanu, L., Bubenek-Turconi, S., Ioana Marina Grintescu,, Cobilinschi, C., Daniela Carmen Filipescu,, Cornelia Elena Predoi,, Tomescu, D., Popescu, M., Marcu, A., Grigoras, I., Lungu, O., Gritsan, A., Anderzhanova, A., Meleshkina, Y., Magomedov, M., Zubareva, N., Tribulev, M., Gaigolnik, D., Eremenko, A., Vistovskaya, N., Chukina, M., Belskiy, V., Furman, M., Ricard Ferrer Rocca,, Martinez, M., Casares, V., Vera, P., Flores, M., Joaquin Amador Amerigo,, Maria Pilar Gracia Arnillas,, Rosana Munoz Bermudez,, Armestar, F., Catalan, B., Roig, R., Raguer, L., María Dolores Quesada,, Emilio Diaz Santos,, Gomà, G., Ubeda, A., Dra Maria Salgado,, Lorena Forcelledo Espina,, Emilio Garcia Prieto,, Dra Mj Asensio,, Rodriguez, D. M., Maseda, E., Alejandro Suarez De La Rica,, Ignacio Ayestaran, J., Novo, M., Miguel Angel Blasco-Navalpotro,, Alberto Orejas Gallego,, Sjövall, F., Spahic, D., Carl Johan Svensson,, Haney, M., Edin, A., Åkerlund, J., Lina De Geer,, Prazak, J., Jakob, S., Pagani, J., Abed-Maillard, S., Akova, M., Abdullah Tarik Aslan,, Timuroglu, A., Kocagoz, S., Kusoglu, H., Mehtap, S., Ceyhun, S., Neriman Defne Altintas,, Talan, L., Kayaaslan, B., Ayşe Kaya Kalem,, Kurt, I., Telli, M., Ozturk, B., Erol, Ç., Emine Kubra Dindar Demiray,, Çolak, S., Akbas, T., Gundogan, K., Sari, A., Agalar, C., Çolak, O., Baykam, N. N., Akdogan, O. O., Yilmaz, M., Tunay, B., Cakmak, R., Saltoglu, N., Karaali, R., Koksal, I., Aksoy, F., Eroglu, A., Kemal Tolga Saracoglu,, Bilir, Y., Guzeldag, S., Ersoz, G., Evik, G., Sungurtekin, H., Ozgen, C., Erdoğan, C., Gürbüz, Y., Altin, N., Bayindir, Y., Ersoy, Y., Goksu, S., Akyol, A., Batirel, A., Sabahat Cagan Aktas,, Andrew Conway Morris,, Routledge, M., Andrew Conway Morris,, Ercole, A., Antcliffe, D., Rojo, R., Tizard, K., Faulkner, M., Cowton, A., Kent, M., Raj, A., Zormpa, A., Tinaslanidis, G., Khade, R., Torlinski, T., Mulhi, R., Goyal, S., Bajaj, M., Soltan, M., Yonan, A., Dolan, R., Johnson, A., Macfie, C., Lennard, J., Templeton, M., Sonia Sousa Arias,, Franke, U., Hugill, K., Angell, H., Parcell, B. J., Cobb, K., Cole, S., Smith, T., Graham, C., Cerman, J., Keegan, A., Ritzema, J., Sanderson, A., Roshdy, A., Szakmany, T., Baumer, T., Longbottom, R., Hall, D., Tatham, K., Loftus, S., Husain, A., Black, E., Jhanji, S., Rao Baikady, R., Mcguigan, P., Mckee, R., Kannan, S., Antrolikar, S., Marsden, N., Valentina Della Torre,, Banach, D., Zaki, A., Jackson, M., Chikungwa, M., Attwood, B., Patel, J., Tilley, R. E., Humphreys, M. S. K., Paul Jean Renaud,, Sokhan, A., Burma, Y., Sligl, W., Baig, N., Mccoshen, L., Kutsogiannis, D. J., Sligl, W., Thompson, P., Hewer, T., Rabbani, R., Shihan Mahmud Redwanul Huq,, Hasan, R., Mohammad Motiul Islam,, Gurjar, M., Baronia, A., Kothari, N., Sharma, A., Karmakar, S., Sharma, P., Nimbolkar, J., Samdani, P., Vaidyanathan, R., Noor Ahmedi Rubina,, Jain, N., Pahuja, M., Singh, R., Shekhar, S., Syed Nabeel Muzaffar,, Ozair, A., Suhail Sarwar Siddiqui,, Bose, P., Datta, A., Rathod, D., Patel, M., Renuka, M. K., Baby, S. K., Dsilva, C., Chandran, J., Ghosh, P., Mukherjee, S., Sheshala, K., Krushna Chandra Misra,, Saidu Yusuf Yakubu,, Euphemia Mgbosoro Ugwu,, Olatosi, J. O., Desalu, I., Asiyanbi, G., Oladimeji, M., Idowu, O., Adeola, F., Melanie Mc Cree,, Ali Adil Ali Karar,, Elfayadh Saidahmed &am, E. S. &., ,, Hamid, H. K. S., Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study, <<INTENSIVE CARE MEDICINE>>, 2023; 49 (2): 178-190. [doi:10.1007/s00134-022-06944-2] [https://hdl.handle.net/10807/304060]
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