This report suggests that SHOC2-mutated patients may display autoimmune phenomena, though triggers leading to the development of a clinically overt autoimmune disease remain obscure. Unfortunately, there is yet no clear consensus as to whether the association with autoimmune thyroiditis, pancreatitis or cytopenia in SHOC2 mutations is coincidental.
Rigante, D., Leoni, C., Onesimo, R., Giorgio, V., Trevisan, V., Zampino, G., Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations, <<AUTOIMMUNITY REVIEWS>>, 2023; 2023 (22(11): 103462): 1-2. [doi:10.1016/j.autrev.2023.103462] [https://hdl.handle.net/10807/257383]
Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations
Rigante, Donato
;Leoni, Chiara;Onesimo, Roberta;Giorgio, Valentina;Zampino, Giuseppe
2023
Abstract
This report suggests that SHOC2-mutated patients may display autoimmune phenomena, though triggers leading to the development of a clinically overt autoimmune disease remain obscure. Unfortunately, there is yet no clear consensus as to whether the association with autoimmune thyroiditis, pancreatitis or cytopenia in SHOC2 mutations is coincidental.
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