Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).
Martini, M., Ferrara, A. M., Giachelia, M., Panieri, E., Siminovitch, K., Galeotti, T., Larocca, L. M., Pani, G., Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients, <<INFLAMMATORY BOWEL DISEASES>>, 2012; 18 (3): 439-448. [doi:10.1002/ibd.21814] [http://hdl.handle.net/10807/25734]
Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients
Martini, Maurizio;Ferrara, Anna Maria;Giachelia, Manuela;Panieri, Emiliano;Galeotti, Tommaso;Larocca, Luigi Maria;Pani, Giovambattista
2012
Abstract
Ulcerative colitis (UC) is associated with colorectal cancer. Chronic inflammation may also play a role in the pathogenesis of sporadic colorectal cancer (SCC), particularly in younger patients (<55 years). We evaluated whether single nucleotide polymorphisms of the OCTN1 and OCTN2 genes are associated with UC, SCC, and with UC cases with cancer progression (UCCP).
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