Differences in gut microbiota between Parkinson's disease (PD) patients and controls seem to depend on multiple – frequently unmeasured – confounders. Monozygotic twins offer a unique model for controlling several factors responsible for interpersonal variation in gut microbiota. Fecal samples from 20 monozygotic twin pairs (N=40) discordant for PD were studied (metagenomic shotgun analysis). Paired-data analysis detected minimal differences in bacterial taxa abundance at species level (Bacteroides pectinophilus [P=0.037], Bifidobacterium pseudocatenulatum [P=0.050] and Bifidobacterium catenulatum [P=0.025]) and in predicted metabolic pathways (primary bile acid biosynthesis [P=0.037]). Additional studies are warranted to understand the role of gut microbiota in the pathogenesis of PD.

Bolliri, C., Fontana, A., Cereda, E., Barichella, M., Cilia, R., Ferri, V., Caronni, S., Calandrella, D., Morelli, L., Pezzoli, G., Gut microbiota in monozygotic twins discordant for Parkinson's disease, <<ANNALS OF NEUROLOGY>>, 2022; (N/A): N/A-N/A. [doi:10.1002/ana.26454] [http://hdl.handle.net/10807/212564]

Gut microbiota in monozygotic twins discordant for Parkinson's disease

Alessandra Fontana;Lorenzo Morelli;
2022

Abstract

Differences in gut microbiota between Parkinson's disease (PD) patients and controls seem to depend on multiple – frequently unmeasured – confounders. Monozygotic twins offer a unique model for controlling several factors responsible for interpersonal variation in gut microbiota. Fecal samples from 20 monozygotic twin pairs (N=40) discordant for PD were studied (metagenomic shotgun analysis). Paired-data analysis detected minimal differences in bacterial taxa abundance at species level (Bacteroides pectinophilus [P=0.037], Bifidobacterium pseudocatenulatum [P=0.050] and Bifidobacterium catenulatum [P=0.025]) and in predicted metabolic pathways (primary bile acid biosynthesis [P=0.037]). Additional studies are warranted to understand the role of gut microbiota in the pathogenesis of PD.
Inglese
Bolliri, C., Fontana, A., Cereda, E., Barichella, M., Cilia, R., Ferri, V., Caronni, S., Calandrella, D., Morelli, L., Pezzoli, G., Gut microbiota in monozygotic twins discordant for Parkinson's disease, <>, 2022; (N/A): N/A-N/A. [doi:10.1002/ana.26454] [http://hdl.handle.net/10807/212564]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/212564
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