Purpose: Our study investigated the contribution that the application of radiomics analysis on post-treatment magnetic resonance imaging can add to the assessments performed by an experienced disease-specific multidisciplinary tumor board (MTB) for the prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Materials and methods: This analysis included consecutively retrospective LARC patients who obtained a complete or near-complete response after nCRT and/or a pCR after surgery between January 2010 and September 2019. A three-step radiomics features selection was performed and three models were generated: a radiomics model (rRM), a multidisciplinary tumor board model (yMTB) and a combined model (CM). The predictive performance of models was quantified using the receiver operating characteristic (ROC) curve, evaluating the area under curve (AUC). Results: The analysis involved 144 LARC patients; a total of 232 radiomics features were extracted from the MR images acquired post-nCRT. The yMTB, rRM and CM predicted pCR with an AUC of 0.82, 0.73 and 0.84, respectively. ROC comparison was not significant (p = 0.6) between yMTB and CM. Conclusion: Radiomics analysis showed good performance in identifying complete responders, which increased when combined with standard clinical evaluation; this increase was not statistically significant but did improve the prediction of clinical response.

Chiloiro, G., Cusumano, D., De Franco, P., Lenkowicz, J., Boldrini, L., Carano, D., Barbaro, B., Corvari, B., Dinapoli, N., Giraffa, M., Meldolesi, E., Manfredi, R., Valentini, V., Gambacorta, M. A., Does restaging MRI radiomics analysis improve pathological complete response prediction in rectal cancer patients? A prognostic model development, <<LA RADIOLOGIA MEDICA>>, 2021; 127 (1): 11-20. [doi:10.1007/s11547-021-01421-0] [http://hdl.handle.net/10807/198511]

Does restaging MRI radiomics analysis improve pathological complete response prediction in rectal cancer patients? A prognostic model development

Chiloiro, Giuditta;Cusumano, Davide;Lenkowicz, Jacopo;Boldrini, Luca;Carano, Davide;Barbaro, Brunella;Dinapoli, Nicola;Meldolesi, Elisa;Manfredi, Riccardo;Valentini, Vincenzo;Gambacorta, Maria Antonietta
2022

Abstract

Purpose: Our study investigated the contribution that the application of radiomics analysis on post-treatment magnetic resonance imaging can add to the assessments performed by an experienced disease-specific multidisciplinary tumor board (MTB) for the prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Materials and methods: This analysis included consecutively retrospective LARC patients who obtained a complete or near-complete response after nCRT and/or a pCR after surgery between January 2010 and September 2019. A three-step radiomics features selection was performed and three models were generated: a radiomics model (rRM), a multidisciplinary tumor board model (yMTB) and a combined model (CM). The predictive performance of models was quantified using the receiver operating characteristic (ROC) curve, evaluating the area under curve (AUC). Results: The analysis involved 144 LARC patients; a total of 232 radiomics features were extracted from the MR images acquired post-nCRT. The yMTB, rRM and CM predicted pCR with an AUC of 0.82, 0.73 and 0.84, respectively. ROC comparison was not significant (p = 0.6) between yMTB and CM. Conclusion: Radiomics analysis showed good performance in identifying complete responders, which increased when combined with standard clinical evaluation; this increase was not statistically significant but did improve the prediction of clinical response.
2022
Inglese
Chiloiro, G., Cusumano, D., De Franco, P., Lenkowicz, J., Boldrini, L., Carano, D., Barbaro, B., Corvari, B., Dinapoli, N., Giraffa, M., Meldolesi, E., Manfredi, R., Valentini, V., Gambacorta, M. A., Does restaging MRI radiomics analysis improve pathological complete response prediction in rectal cancer patients? A prognostic model development, <<LA RADIOLOGIA MEDICA>>, 2021; 127 (1): 11-20. [doi:10.1007/s11547-021-01421-0] [http://hdl.handle.net/10807/198511]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/198511
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