Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. Materials and Methods: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. Results: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. Conclusions: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time.

Brogna, C., Cristiano, L., Verdolotti, T., Norcia, G., Ficociello, L., Ruiz, R. G., Coratti, G., Fanelli, L., Forcina, N., Petracca, G., Chieppa, F., Tartaglione, T., Colosimo, C., Pane, M., Mercuri, E. M., Longitudinal motor functional outcomes and magnetic resonance imaging patterns of muscle involvement in upper limbs in duchenne muscular dystrophy, <<MEDICINA>>, 2021; 57 (11): 1267-1267. [doi:10.3390/medicina57111267] [http://hdl.handle.net/10807/197888]

Longitudinal motor functional outcomes and magnetic resonance imaging patterns of muscle involvement in upper limbs in duchenne muscular dystrophy

Brogna, Claudia;Cristiano, Lara;Verdolotti, Tommaso;Ficociello, Luana;Ruiz, Roberta Giusy;Coratti, Giorgia;Fanelli, Lavinia;Petracca, Giorgia;Chieppa, Fabrizia;Tartaglione, Tommaso;Colosimo, Cesare;Pane, Marika;Mercuri, Eugenio Maria
2021

Abstract

Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant Duchenne Muscular Dystrophy (DMD) patients. We also wished to define whether baseline muscle MRI could help to predict functional changes after one year. Materials and Methods: Twenty-seven patients had both baseline and 12month muscle MRI and PUL assessments one year later. Results: Ten were ambulant (age range 5–16 years), and 17 non ambulant (age range 10–30 years). Increased abnormalities equal or more than 1.5 point on muscle MRI at follow up were found on all domains: at shoulder level 12/27 patients (44%), at arm level 4/27 (15%) and at forearm level 6/27 (22%). Lower follow up PUL score were found in 8/27 patients (30%) at shoulder level, in 9/27 patients (33%) at mid-level whereas no functional changes were found at distal level. There was no constant association between baseline MRI scores and follow up PUL scores at arm and forearm levels but at shoulder level patients with moderate impairment on the baseline MRI scores between 16 and 34 had the highest risk of decreased function on PUL over a year. Conclusions: Our results confirmed that the integrated use of functional scales and imaging can help to monitor functional and MRI changes over time.
2021
Inglese
Brogna, C., Cristiano, L., Verdolotti, T., Norcia, G., Ficociello, L., Ruiz, R. G., Coratti, G., Fanelli, L., Forcina, N., Petracca, G., Chieppa, F., Tartaglione, T., Colosimo, C., Pane, M., Mercuri, E. M., Longitudinal motor functional outcomes and magnetic resonance imaging patterns of muscle involvement in upper limbs in duchenne muscular dystrophy, <<MEDICINA>>, 2021; 57 (11): 1267-1267. [doi:10.3390/medicina57111267] [http://hdl.handle.net/10807/197888]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/197888
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