A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
Bellesi, S., Metafuni, E., Hohaus, S., Maiolo, E., Marchionni, F., D'Innocenzo, S., La Sorda, M., Ferraironi, M., Ramundo, F., Fantoni, M., Murri, R., Cingolani, A., Sica, S., Gasbarrini, A., Sanguinetti, M., Chiusolo, P., De Stefano, V., Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients, <<BRITISH JOURNAL OF HAEMATOLOGY>>, 2020; 191 (2): 207-211. [doi:10.1111/bjh.17034] [http://hdl.handle.net/10807/166626]
Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients
Bellesi, Silvia;Metafuni, Elisabetta;Hohaus, Stefan;Ramundo, Francesco;Fantoni, M.;Murri, Rita;Cingolani, Antonella;Sica, Simona;Gasbarrini, Antonio;Sanguinetti, Maurizio;Chiusolo, Patrizia;De Stefano, Valerio
2020
Abstract
A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
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