Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and self-limiting benign disorder that most commonly involves the cervical lymph nodes. The authors describe two cases of SHML. Fine-needle aspiration of the lymphadenopathy was performed in both patients. Immunocytochemical and histologic features, as the evidence of emperipolesis and S100 protein positivity on immunostaining, were typical of SHML. Fine-needle aspiration cytology plays an important diagnostic role in SHML and may be conclusive in a typical clinical setting. The diagnosis of SHML should be considered in the differential diagnosis of massive, painless cervical lymphadenopathy. Long-term follow-up is necessary to observe the complete regression of the massive lymphadenopathy. However, specific therapy is available and should be limited to patients with compressive symptoms or extranodal disease.

Ruggiero, A., Attinà, G., Maurizi, P., Mulé, A., Tarquini, E., Barone, G., Lazzareschi, I., Riccardi, R., Rosai-Dorfman Disease. Two Case Report and Diagnostic Role of Fine-Needle Aspiration Cytology., <<JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY>>, 2006; (28(2)): 103-106 [http://hdl.handle.net/10807/16192]

Rosai-Dorfman Disease. Two Case Report and Diagnostic Role of Fine-Needle Aspiration Cytology.

Ruggiero, Antonio;Maurizi, Palma;Tarquini, Elisabetta;Barone, Giuseppe;Lazzareschi, Ilaria;Riccardi, Riccardo
2006

Abstract

Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML), is a rare and self-limiting benign disorder that most commonly involves the cervical lymph nodes. The authors describe two cases of SHML. Fine-needle aspiration of the lymphadenopathy was performed in both patients. Immunocytochemical and histologic features, as the evidence of emperipolesis and S100 protein positivity on immunostaining, were typical of SHML. Fine-needle aspiration cytology plays an important diagnostic role in SHML and may be conclusive in a typical clinical setting. The diagnosis of SHML should be considered in the differential diagnosis of massive, painless cervical lymphadenopathy. Long-term follow-up is necessary to observe the complete regression of the massive lymphadenopathy. However, specific therapy is available and should be limited to patients with compressive symptoms or extranodal disease.
Inglese
Ruggiero, A., Attinà, G., Maurizi, P., Mulé, A., Tarquini, E., Barone, G., Lazzareschi, I., Riccardi, R., Rosai-Dorfman Disease. Two Case Report and Diagnostic Role of Fine-Needle Aspiration Cytology., <<JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY>>, 2006; (28(2)): 103-106 [http://hdl.handle.net/10807/16192]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/16192
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