Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes underlying (syndromic and non-syndromic) intellectual disability, it provides a succinct analysis of their Gene Ontology, and it suggests the use of transcriptional profiling for the prioritization of candidate genes.

Chiurazzi, P., Pirozzi, F., Advances in understanding - genetic basis of intellectual disability, <<F1000RESEARCH>>, 2016; 5 (N/A): 599-N/A. [doi:10.12688/f1000research.7134.1] [http://hdl.handle.net/10807/95367]

Advances in understanding - genetic basis of intellectual disability

Chiurazzi, Pietro
;
Pirozzi, Filomena
Ultimo
2016

Abstract

Intellectual disability is the most common developmental disorder characterized by a congenital limitation in intellectual functioning and adaptive behavior. It often co-occurs with other mental conditions like attention deficit/hyperactivity disorder and autism spectrum disorder, and can be part of a malformation syndrome that affects other organs. Considering the heterogeneity of its causes (environmental and genetic), its frequency worldwide varies greatly. This review focuses on known genes underlying (syndromic and non-syndromic) intellectual disability, it provides a succinct analysis of their Gene Ontology, and it suggests the use of transcriptional profiling for the prioritization of candidate genes.
Inglese
Chiurazzi, P., Pirozzi, F., Advances in understanding - genetic basis of intellectual disability, <<F1000RESEARCH>>, 2016; 5 (N/A): 599-N/A. [doi:10.12688/f1000research.7134.1] [http://hdl.handle.net/10807/95367]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/95367
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