Background: Obese children are subject to the same chronic oxidative and inflammatory stress, responsible for the onset of all the complications typical of adult age, such as insulin resistance, type 2 diabetes, dyslipidemia and cardiovascular disease. Objectives: Since few studies are reported in prepubertal obese children, we investigated the relationship between oxidative stress, body composition and metabolic pattern in childhood obesity in comparison with adult obese patients. Methods: We enrolled 25 prepubertal children (12 males and 13 females) aged 5-12 years with a mean value of standard deviation of BMI (SDS-BMI)±SEM of 1.96±0.09. We performed oral glucose tolerance test, hormonal and metabolic evaluation, bioimpedentiometry, evaluation of total antioxidant capacity using spectroscopical method using a radical cation, 2,2I- azinobis(3-ethylbenzothiazoline-6 sulphonate) (ABTS), as indicator of radical formation, with a latency time (LAG) proportional to antioxidant in the sample. Results: LAG values significantly correlate with % fat mass, waist circumference and waist/hip ratio. However mean LAG values were significantly lower than in obese adults. Conclusions: We suggest that children are more susceptible to oxidative stress than adults, possibly to incomplete development of antioxidant system. Prognostic and therapeutical implications need to be further investigated.

Leo, F., Rossodivita, A. N., Segni, C. D., Raimondo, S., Canichella, S., Silvestrini, A., Miggiano, G. A. D., Meucci Calabrese, E., Mancini, A., Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in Pediatric Obesity, <<EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES>>, 2016; 124 (8): 481-486. [doi:10.1055/s-0042-105280] [http://hdl.handle.net/10807/94219]

Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in Pediatric Obesity

Rossodivita, Aurora Natalia
Secondo
;
Raimondo, Sebastiano;Silvestrini, Andrea
;
Miggiano, Giacinto Abele Donato;Meucci Calabrese, Elisabetta
Penultimo
;
Mancini, Antonio
Ultimo
2016

Abstract

Background: Obese children are subject to the same chronic oxidative and inflammatory stress, responsible for the onset of all the complications typical of adult age, such as insulin resistance, type 2 diabetes, dyslipidemia and cardiovascular disease. Objectives: Since few studies are reported in prepubertal obese children, we investigated the relationship between oxidative stress, body composition and metabolic pattern in childhood obesity in comparison with adult obese patients. Methods: We enrolled 25 prepubertal children (12 males and 13 females) aged 5-12 years with a mean value of standard deviation of BMI (SDS-BMI)±SEM of 1.96±0.09. We performed oral glucose tolerance test, hormonal and metabolic evaluation, bioimpedentiometry, evaluation of total antioxidant capacity using spectroscopical method using a radical cation, 2,2I- azinobis(3-ethylbenzothiazoline-6 sulphonate) (ABTS), as indicator of radical formation, with a latency time (LAG) proportional to antioxidant in the sample. Results: LAG values significantly correlate with % fat mass, waist circumference and waist/hip ratio. However mean LAG values were significantly lower than in obese adults. Conclusions: We suggest that children are more susceptible to oxidative stress than adults, possibly to incomplete development of antioxidant system. Prognostic and therapeutical implications need to be further investigated.
2016
Inglese
Leo, F., Rossodivita, A. N., Segni, C. D., Raimondo, S., Canichella, S., Silvestrini, A., Miggiano, G. A. D., Meucci Calabrese, E., Mancini, A., Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in Pediatric Obesity, <<EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES>>, 2016; 124 (8): 481-486. [doi:10.1055/s-0042-105280] [http://hdl.handle.net/10807/94219]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/94219
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