Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with thrombolysis for PE and heparin. APL has been processed with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) obtaining complete remission.
Sora', F., Chiusolo, P., Laurenti, L., Autore, F., Giammarco, S., Sica, S., Massive Pulmonary Embolism at the Onset of Acute Promyelocytic Leukemia, <<MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES>>, 2016; 8 (1): e2016027-e2016027. [doi:10.4084/MJHID.2016.027] [http://hdl.handle.net/10807/92723]
Massive Pulmonary Embolism at the Onset of Acute Promyelocytic Leukemia
Sora', FedericaPrimo
;Chiusolo, PatriziaSecondo
;Laurenti, Luca;Autore, Francesco;Giammarco, SabrinaPenultimo
;Sica, SimonaUltimo
2016
Abstract
Life-threatening bleeding is a major and early complication of acute promyelocytic leukemia (APL), but in the last years there is a growing evidence of thromboses in APL. We report the first case of a young woman with dyspnea as the first symptom of APL due to massive pulmonary embolism (PE) successfully treated with thrombolysis for PE and heparin. APL has been processed with a combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) obtaining complete remission.
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