OBJECTIVES: To assess the inter-individual and intra-individual plasma concentration variabilities of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) in routine clinical practice and to investigate their relationships with virological failure. METHODS: We retrospectively enrolled HIV-infected patients undergoing therapeutic drug monitoring (TDM) of NNRTIs and PIs during routine outpatient visits. Plasma drug concentrations were measured by HPLC-UV and were considered therapeutic if above the proposed minimum efficacy trough concentration. Inter-individual and intra-individual variabilities were evaluated through the coefficient of variation (CV). RESULTS: A total of 457 PI and 172 NNRTI plasma concentrations were measured from 363 patients (HIV-RNA <50 copies/mL in 70.8%, median CD4 count 434 cells/mm(3)). NNRTIs showed less inter-individual (CV(inter) 54.8% versus 84.3%) and intra-individual (CV(intra) 19.0% versus 38.1%) pharmacokinetic variabilities

Fabbiani, M., Di Giambenedetto, S., Bracciale, L., Bacarelli, A., Ragazzoni, E., Cauda, R., Navarra, P., De Luca, A., Pharmacokinetic variability of antiretroviral drugs and correlation with virological outcome: two years experience in routine clinical practice, <<JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY>>, 2009; (Aprile): 109-117 [http://hdl.handle.net/10807/9018]

Pharmacokinetic variability of antiretroviral drugs and correlation with virological outcome: two years experience in routine clinical practice

Fabbiani, Massimiliano;Di Giambenedetto, Simona;Bracciale, Laura;Bacarelli, Alessandra;Ragazzoni, Enzo;Cauda, Roberto;Navarra, Pierluigi;De Luca, Andrea
2009

Abstract

OBJECTIVES: To assess the inter-individual and intra-individual plasma concentration variabilities of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) in routine clinical practice and to investigate their relationships with virological failure. METHODS: We retrospectively enrolled HIV-infected patients undergoing therapeutic drug monitoring (TDM) of NNRTIs and PIs during routine outpatient visits. Plasma drug concentrations were measured by HPLC-UV and were considered therapeutic if above the proposed minimum efficacy trough concentration. Inter-individual and intra-individual variabilities were evaluated through the coefficient of variation (CV). RESULTS: A total of 457 PI and 172 NNRTI plasma concentrations were measured from 363 patients (HIV-RNA <50 copies/mL in 70.8%, median CD4 count 434 cells/mm(3)). NNRTIs showed less inter-individual (CV(inter) 54.8% versus 84.3%) and intra-individual (CV(intra) 19.0% versus 38.1%) pharmacokinetic variabilities
2009
Inglese
Fabbiani, M., Di Giambenedetto, S., Bracciale, L., Bacarelli, A., Ragazzoni, E., Cauda, R., Navarra, P., De Luca, A., Pharmacokinetic variability of antiretroviral drugs and correlation with virological outcome: two years experience in routine clinical practice, <<JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY>>, 2009; (Aprile): 109-117 [http://hdl.handle.net/10807/9018]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/9018
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