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EnglishPURPOSE: To investigate whether prefrontal cortex (PFC) functioning during ataxic gait is linked to compensatory mechanisms or to the typical intra-subject variability of the ataxic gait. METHODS: Nineteen patients with chronic ataxia and fifteen healthy subjects were evaluated. The subjects were requested to walk along a straight distance of 10 meters while PFC oxygenation and gait parameters were assessed. PFC activity was evaluated by NIRO-200 while gait analysis was performed by the SMART-D500. To investigate the intra-subject variability of gait, we calculated the coefficient of multiple correlation (CMC) of the hip, knee and ankle kinematic waveforms furthermore, we evaluated the step width. RESULTS: We observed a positive correlation between PFC bilateral oxygenation changes and the step width (r = 0.54; p = 0.02 for the right PFC, and r = 0.50; p = 0.03 for the left PFC). No correlation was found between PFC activity and CMC of the hip, knee and ankle waveforms. CONCLUSIONS: Our results suggest that PFC activity is linked to gait compensatory mechanisms more than to the variability of the joint kinematic parameters caused by a defective cerebellar control.
Caliandro, P., Serrao, M., Padua, L., Silvestri, G., Iacovelli, C., Simbolotti, C., Mari, S., Reale, G., Casali, C., Rossini, P. M., Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters, <<RESTORATIVE NEUROLOGY AND NEUROSCIENCE>>, 2015; 33 (2): 177-187. [doi:10.3233/RNN-140449] [http://hdl.handle.net/10807/86707]
| Autori: | ||
| Titolo: | Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3233/RNN-140449 | |
| Data di pubblicazione: | 2015 | |
| Abstract: | PURPOSE: To investigate whether prefrontal cortex (PFC) functioning during ataxic gait is linked to compensatory mechanisms or to the typical intra-subject variability of the ataxic gait. METHODS: Nineteen patients with chronic ataxia and fifteen healthy subjects were evaluated. The subjects were requested to walk along a straight distance of 10 meters while PFC oxygenation and gait parameters were assessed. PFC activity was evaluated by NIRO-200 while gait analysis was performed by the SMART-D500. To investigate the intra-subject variability of gait, we calculated the coefficient of multiple correlation (CMC) of the hip, knee and ankle kinematic waveforms furthermore, we evaluated the step width. RESULTS: We observed a positive correlation between PFC bilateral oxygenation changes and the step width (r = 0.54; p = 0.02 for the right PFC, and r = 0.50; p = 0.03 for the left PFC). No correlation was found between PFC activity and CMC of the hip, knee and ankle waveforms. CONCLUSIONS: Our results suggest that PFC activity is linked to gait compensatory mechanisms more than to the variability of the joint kinematic parameters caused by a defective cerebellar control. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Caliandro, P., Serrao, M., Padua, L., Silvestri, G., Iacovelli, C., Simbolotti, C., Mari, S., Reale, G., Casali, C., Rossini, P. M., Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters, <<RESTORATIVE NEUROLOGY AND NEUROSCIENCE>>, 2015; 33 (2): 177-187. [doi:10.3233/RNN-140449] [http://hdl.handle.net/10807/86707] | |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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