IgM-related neuropathy generally presents as a late-onset demyelinating polyneuropathy with predominant sensory loss and ataxia. However, we recently reported the clinical, neurophysiological and pathological findings from our cohort and identified in about a third of patients an atypical phenotype. We analyzed by flow cytometry the different lymphocytes subsets in the peripheral blood of patients affected by IgM-related neuropathy, chronic inflammatory demyelinating polyneuropathy (CIDP), monoclonal gammopathy of undetermined significance and healthy subjects, to investigate whether different immunological patterns may differentiate the classical phenotype from atypical forms. IFN-gamma producing CD4+ and CD8+ T lymphocytes, as well as CD4+ and CD8+ T cells expressing T-bet (T-helper type 1, Th1) were increased in CIDP patients. The percentage of circulating CD4+ and CD8+ T cells producing IL-10 as well as the percentage of CD19+ cells expressing Blimp-1 were higher in patients with IgM-neuropathy. We did not find any significant differences in the different lymphocytes subsets in the IgM-related neuropathy between patients with classical and atypical phenotype. Th1 cells are increased in CIDP patients while a T helper type 2-phenotype seems to prevail in patients with IgM-neuropathy. Further studies involving a larger patient population are needed to evaluate if different lymphocytes subset may be involved in different clinical phenotypes of IgM-related neuropathy.

Iorio, R., Sabatelli, M., Del Grande, A., Bisogni, G., Damato, V., Plantone, D., Marti, A., Frisullo, G., Romano, A., Rossini, P. M., Luigetti, M., Distinct lymphocytes subsets in IgM-related neuropathy: clinical-immunological correlations, <<NEUROLOGICAL SCIENCES>>, 2015; 36 (2): 303-308. [doi:10.1007/s10072-014-1935-x] [http://hdl.handle.net/10807/86157]

Distinct lymphocytes subsets in IgM-related neuropathy: clinical-immunological correlations

Iorio, Raffaele
Primo
;
Sabatelli, Mario
Secondo
;
Del Grande, Alessandra;Bisogni, Giulia;Damato, Valentina;Plantone, Domenico;Marti, Alessandro;Frisullo, Giovanni;Romano, Angela;Rossini, Paolo Maria
Penultimo
;
Luigetti, Marco
Ultimo
2015

Abstract

IgM-related neuropathy generally presents as a late-onset demyelinating polyneuropathy with predominant sensory loss and ataxia. However, we recently reported the clinical, neurophysiological and pathological findings from our cohort and identified in about a third of patients an atypical phenotype. We analyzed by flow cytometry the different lymphocytes subsets in the peripheral blood of patients affected by IgM-related neuropathy, chronic inflammatory demyelinating polyneuropathy (CIDP), monoclonal gammopathy of undetermined significance and healthy subjects, to investigate whether different immunological patterns may differentiate the classical phenotype from atypical forms. IFN-gamma producing CD4+ and CD8+ T lymphocytes, as well as CD4+ and CD8+ T cells expressing T-bet (T-helper type 1, Th1) were increased in CIDP patients. The percentage of circulating CD4+ and CD8+ T cells producing IL-10 as well as the percentage of CD19+ cells expressing Blimp-1 were higher in patients with IgM-neuropathy. We did not find any significant differences in the different lymphocytes subsets in the IgM-related neuropathy between patients with classical and atypical phenotype. Th1 cells are increased in CIDP patients while a T helper type 2-phenotype seems to prevail in patients with IgM-neuropathy. Further studies involving a larger patient population are needed to evaluate if different lymphocytes subset may be involved in different clinical phenotypes of IgM-related neuropathy.
Inglese
Iorio, R., Sabatelli, M., Del Grande, A., Bisogni, G., Damato, V., Plantone, D., Marti, A., Frisullo, G., Romano, A., Rossini, P. M., Luigetti, M., Distinct lymphocytes subsets in IgM-related neuropathy: clinical-immunological correlations, <<NEUROLOGICAL SCIENCES>>, 2015; 36 (2): 303-308. [doi:10.1007/s10072-014-1935-x] [http://hdl.handle.net/10807/86157]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/86157
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