The use of NSAID,s in the postoperative period:advantage and sdisfantages.

NSAIDs are commonly used as single analgesics in minor surgery or as component of multimodal analgesia with opioids or locoregional techniques in the postoperative period to assure a better analgesia and reduce the dose of opioids. The analgesic potency evaluated as number needed to treat (NNT) is not very different between the traditional non selective NSAIDs and the selective cyclo-oxygenase-2-inhibitors (Coxibs). The effectiveness as analgesic is unquestionable also if these drugs are not devoid to risk. There is debate in literature about the possible side effects when administrered in the perioperative period: anastomotic leakage, reduced ossification, bleeding and acute renal failure. Recent data underline ad the Coxibs but also traditional NSAIDs can induce cardiac toxicity even if they are utilizrd for few days. The aim of this review is to provide an overview of the effectiveness and side effects of selectie and nonselective NSAIDs in the perioperative period