Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. The v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) valine (V) to glutamic acid (E) substitution at codon 600 (BRAF(V600E)) is the most effective diagnostic/prognostic marker and is used mainly for papillary thyroid carcinomas (PTCs). Although BRAF(V600E) represents 95% of all BRAF mutations, uncommon BRAF mutations have been identified in thyroid carcinomas. For the current study, the authors evaluated morphologic (plump pink cells and sickle-shaped nuclei) anti-BRAF(V600E) antibody (VE1) immunocytochemical and molecular findings of BRAF mutations in PTCs and in the follicular variant of PTC (FVPC).

Rossi, E., Martini, M., Bizzarro, T., Capodimonti, S., Cenci, T., Lombardi, C. P., Pontecorvi, A., Fadda, G., Larocca, L. M., Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights, <<CANCER CYTOPATHOLOGY>>, 2015; 123 (10): 593-602. [doi:10.1002/cncy.21586] [http://hdl.handle.net/10807/70156]

Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights

Rossi, Esther;Martini, Maurizio;Bizzarro, Tommaso;Capodimonti, Sara;Cenci, Tonia;Lombardi, Celestino Pio;Pontecorvi, Alfredo;Fadda, Guido;Larocca, Luigi Maria
2015

Abstract

Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. The v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) valine (V) to glutamic acid (E) substitution at codon 600 (BRAF(V600E)) is the most effective diagnostic/prognostic marker and is used mainly for papillary thyroid carcinomas (PTCs). Although BRAF(V600E) represents 95% of all BRAF mutations, uncommon BRAF mutations have been identified in thyroid carcinomas. For the current study, the authors evaluated morphologic (plump pink cells and sickle-shaped nuclei) anti-BRAF(V600E) antibody (VE1) immunocytochemical and molecular findings of BRAF mutations in PTCs and in the follicular variant of PTC (FVPC).
Inglese
Rossi, E., Martini, M., Bizzarro, T., Capodimonti, S., Cenci, T., Lombardi, C. P., Pontecorvi, A., Fadda, G., Larocca, L. M., Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights, <>, 2015; 123 (10): 593-602. [doi:10.1002/cncy.21586] [http://hdl.handle.net/10807/70156]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/70156
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