Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.
Bizzarro, T., Martini, M., Marrocco, C., D'Amato, D., Traini, E., Lombardi, C. P., Pontecorvi, A., Fadda, G., Larocca, L. M., Rossi, E., The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology, <<PLOS ONE>>, 2015; 10 (7): e0132939-e0132939. [doi:10.1371/journal.pone.0132939] [http://hdl.handle.net/10807/70155]
The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology
Bizzarro, Tommaso;Martini, Maurizio;Traini, Emanuela;Lombardi, Celestino Pio;Pontecorvi, Alfredo;Fadda, Guido;Larocca, Luigi Maria;Rossi, Esther
2015
Abstract
Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.
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