Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.

Bizzarro, T., Martini, M., Marrocco, C., D'amato, D., Traini, E., Lombardi, C. P., Pontecorvi, A., Fadda, G., Larocca, L. M., Rossi, E., The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology, <<PLOS ONE>>, 2015; 10 (7): e0132939-e0132939. [doi:10.1371/journal.pone.0132939] [http://hdl.handle.net/10807/70155]

The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology

Bizzarro;Tommaso; Martini;D; Traini;Emanuela; Lombardi;Celestino Pio; Pontecorvi;Alfredo; Fadda;Guido; Larocca;Luigi Maria; Rossi
2015

Abstract

Fine needle aspiration Cytology (FNAC) fulfills a reliable role in the evaluation of thyroid lesions. Although the majority of nodules are quite easily diagnosed as benign or malignant, 30% of them represent an indeterminate category whereby the application of ancillary techniques (i.e. immunocytochemistry-ICC and molecular testing) has been encouraged. The search for a specific immunomarker of malignancy sheds light on a huge number of ICC stains although none of them attempt to yield 100% conclusive results. Our aim was to define in a pilot study on thyroid FNAC whether CD56 might be a valid marker also in comparison with HBME-1 and Galectin-3.
Inglese
Bizzarro, T., Martini, M., Marrocco, C., D'amato, D., Traini, E., Lombardi, C. P., Pontecorvi, A., Fadda, G., Larocca, L. M., Rossi, E., The Role of CD56 in Thyroid Fine Needle Aspiration Cytology: A Pilot Study Performed on Liquid Based Cytology, <<PLOS ONE>>, 2015; 10 (7): e0132939-e0132939. [doi:10.1371/journal.pone.0132939] [http://hdl.handle.net/10807/70155]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/70155
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