Purpose: To investigate whether prefrontal cortex (PFC) functioning during ataxic gait is linked to compensatory mechanisms or to the typical intra-subject variability of the ataxic gait. Methods: Nineteen patients with chronic ataxia and fifteen healthy subjects were evaluated. The subjects were requested to walk along a straight distance of 10 meters while PFC oxygenation and gait parameters were assessed. PFC activity was evaluated by NIRO-200 while gait analysis was performed by the SMART-D500. To investigate the intra-subject variability of gait, we calculated the coefficient of multiple correlation (CMC) of the hip, knee and ankle kinematic waveforms furthermore, we evaluated the step width. Results: We observed a positive correlation between PFC bilateral oxygenation changes and the step width (r = 0.54; p = 0.02 for the right PFC, and r = 0.50; p = 0.03 for the left PFC). No correlation was found between PFC activity and CMC of the hip, knee and ankle waveforms. Conclusions: Our results suggest that PFC activity is linked to gait compensatory mechanisms more than to the variability of the joint kinematic parameters caused by a defective cerebellar control.

Caliandro, P., Mariano, S., Padua, L., Silvestri, G., Iacovelli, C., Simbolotti, C., Mari, S., Reale, G., Casali, C., Rossini, P. M., Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters, <<RESTORATIVE NEUROLOGY AND NEUROSCIENCE>>, 2015; 33 (2): 177-187. [doi:10.3233/RNN-140449] [http://hdl.handle.net/10807/68080]

Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters

Caliandro, Pietro;Padua, Luca;Silvestri, Gabriella;Iacovelli, Chiara;Rossini, Paolo Maria
2015

Abstract

Purpose: To investigate whether prefrontal cortex (PFC) functioning during ataxic gait is linked to compensatory mechanisms or to the typical intra-subject variability of the ataxic gait. Methods: Nineteen patients with chronic ataxia and fifteen healthy subjects were evaluated. The subjects were requested to walk along a straight distance of 10 meters while PFC oxygenation and gait parameters were assessed. PFC activity was evaluated by NIRO-200 while gait analysis was performed by the SMART-D500. To investigate the intra-subject variability of gait, we calculated the coefficient of multiple correlation (CMC) of the hip, knee and ankle kinematic waveforms furthermore, we evaluated the step width. Results: We observed a positive correlation between PFC bilateral oxygenation changes and the step width (r = 0.54; p = 0.02 for the right PFC, and r = 0.50; p = 0.03 for the left PFC). No correlation was found between PFC activity and CMC of the hip, knee and ankle waveforms. Conclusions: Our results suggest that PFC activity is linked to gait compensatory mechanisms more than to the variability of the joint kinematic parameters caused by a defective cerebellar control.
Inglese
Caliandro, P., Mariano, S., Padua, L., Silvestri, G., Iacovelli, C., Simbolotti, C., Mari, S., Reale, G., Casali, C., Rossini, P. M., Prefrontal cortex as a compensatory network in ataxic gait: a correlation study between cortical activity and gait parameters, <>, 2015; 33 (2): 177-187. [doi:10.3233/RNN-140449] [http://hdl.handle.net/10807/68080]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/68080
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 15
social impact