Abstract During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.

Pietta, E., Montealegre, M., Cocconcelli, P. S., Murray, B., Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R., <<ANTIMICROBIAL AGENTS AND CHEMOTHERAPY>>, 2014; 58 (11): 6978-6981. [doi:10.1128/AAC.03648-14] [http://hdl.handle.net/10807/64786]

Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.

Pietta, Ester;Cocconcelli, Pier Sandro;
2014

Abstract

Abstract During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.
2014
Inglese
Pietta, E., Montealegre, M., Cocconcelli, P. S., Murray, B., Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R., <<ANTIMICROBIAL AGENTS AND CHEMOTHERAPY>>, 2014; 58 (11): 6978-6981. [doi:10.1128/AAC.03648-14] [http://hdl.handle.net/10807/64786]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/64786
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