Objective To investigate the efficacy of a proactive feeding regimen (PFR) in reducing hospital length of stay in a population of moderately preterm small for gestational age (SGA) infants. Study design SGA infants (z-score < 1.28) of gestational age (GA) 32-36 weeks and birth weight (BW) >1499 g were allocated at random to receive either a PFR, starting with 100 mL/kg/day and gradually increasing to 200 mL/ kg/day by day 4, or a standard feeding regimen, starting with 60 mL/kg/day and gradually increasing to 170 mL/kg/ day by day 9. All infants received human milk. Results A total of 72 infants were randomized to the 2 groups, 36 to the PFR group (mean GA, 35.1 0.7 weeks; mean BW, 1761 177 g) and 36 to the standard feeding regimen group (mean GA, 35.5 1.2 weeks; mean BW, 1754 212 g). Infants in the PFR group were discharged significantly earlier (mean, 9.8 3.1 days vs 11.9 4.7 days; P = .029). The need for intravenous fluids (2.8% vs 33.3%; P = .0013) and the incidence of hypoglycemia (0 vs 33.3%; P = .00016) were significantly lower in the PFR group. Feeding intolerance and fecal calprotectin levels did not differ between the 2 groups. Conclusion A PFR in moderately preterm SGA infants is well tolerated and significantly reduces both the length of stay and the risk of neonatal hypoglycemia.

Zecca, E., Costa, S., Barone, G., Giordano, L., Zecca, C., Maggio, L., Proactive enteral nutrition in moderately preterm small for gestational age infants: a randomized clinical trial., <<THE JOURNAL OF PEDIATRICS>>, 2014; 165 (6): 1135-1139.e1. [doi:10.1016/j.jpeds.2014.08.065] [http://hdl.handle.net/10807/63708]

Proactive enteral nutrition in moderately preterm small for gestational age infants: a randomized clinical trial.

Zecca, Enrico;Costa, Simonetta;Barone, Giovanni;Giordano, Lucia;Zecca, Chiara;Maggio, Luca
2014

Abstract

Objective To investigate the efficacy of a proactive feeding regimen (PFR) in reducing hospital length of stay in a population of moderately preterm small for gestational age (SGA) infants. Study design SGA infants (z-score < 1.28) of gestational age (GA) 32-36 weeks and birth weight (BW) >1499 g were allocated at random to receive either a PFR, starting with 100 mL/kg/day and gradually increasing to 200 mL/ kg/day by day 4, or a standard feeding regimen, starting with 60 mL/kg/day and gradually increasing to 170 mL/kg/ day by day 9. All infants received human milk. Results A total of 72 infants were randomized to the 2 groups, 36 to the PFR group (mean GA, 35.1 0.7 weeks; mean BW, 1761 177 g) and 36 to the standard feeding regimen group (mean GA, 35.5 1.2 weeks; mean BW, 1754 212 g). Infants in the PFR group were discharged significantly earlier (mean, 9.8 3.1 days vs 11.9 4.7 days; P = .029). The need for intravenous fluids (2.8% vs 33.3%; P = .0013) and the incidence of hypoglycemia (0 vs 33.3%; P = .00016) were significantly lower in the PFR group. Feeding intolerance and fecal calprotectin levels did not differ between the 2 groups. Conclusion A PFR in moderately preterm SGA infants is well tolerated and significantly reduces both the length of stay and the risk of neonatal hypoglycemia.
2014
Inglese
Zecca, E., Costa, S., Barone, G., Giordano, L., Zecca, C., Maggio, L., Proactive enteral nutrition in moderately preterm small for gestational age infants: a randomized clinical trial., <<THE JOURNAL OF PEDIATRICS>>, 2014; 165 (6): 1135-1139.e1. [doi:10.1016/j.jpeds.2014.08.065] [http://hdl.handle.net/10807/63708]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/63708
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