Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.
Prosperi, M., Mackie, N., Di Giambenedetto, S., Zazzi, M., Camacho, R., Fanti, I., Torti, C., Sönnerborg, A., Kaiser, R., Codoñer, F., Van Laethem, K., Bansi, L., Van De Vijver, D., Geretti, A., De Luca, A., Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study, <<JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY>>, 2011; 66 (8): 1886-1896. [doi:10.1093/jac/dkr171] [http://hdl.handle.net/10807/6356]
Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study
Di Giambenedetto, Simona;Fanti, Iuri;De Luca, Andrea
2011
Abstract
Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load <1000 copies/mL.
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