We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.
Di Giambenedetto, S., Prosperi, M., Fanti, I., Bruzzone, B., Paolucci, S., Penco, G., Meini, G., Di Biagio, A., Paolini, E., Micheli, V., Meraviglia, P., Castelli, P., Corsi, P., Gonnelli, A., Fabbiani, M., Zazzi, M., De Luca, A., Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009, <<CLINICAL MICROBIOLOGY AND INFECTION>>, 2012; 17 (9): 1352-1355. [doi:10.1111/j.1469-0691.2011.03563.x] [http://hdl.handle.net/10807/6339]
Update on emergence of HIV-1 resistance to antiretroviral drug classes in an Italian national database: 2007-2009
Di Giambenedetto, Simona;Fanti, Iuri;Fabbiani, Massimiliano;De Luca, Andrea
2011
Abstract
We analysed trends of human immunodeficiency virus type 1 (HIV-1) drug resistance during 2007-2009 in the Italian national HIV drug resistance database 'ARCA'. Prevalence of resistance in each year was examined on the basis of the presence of major International AIDS Society-2009 mutations. Predictors of resistance were analysed by multivariable logistic regression. Nine hundred and sixty-six patients were selected. Resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors showed a significant decline with respect to previous surveys. Resistance to any class of drug and three drug classes remained stable. Independent predictors of three-class resistance were the number of treatment regimens experienced, prior suboptimal nucleoside reverse transcriptase inhibitor therapy and the current use of ritonavir-boosted protease inhibitors.
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