We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).

Voso, M. T., Gumiero, D., D'alo', F., Guidi, F., Mansueto, G. R., Di Febo, A., Massini, G., Martini, M., Larocca, L. M., Hohaus, S., Leone, G., DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma., <<HAEMATOLOGICA>>, 2006; (Settembre): 1252-1256 [http://hdl.handle.net/10807/6335]

DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma.

Voso, Maria Teresa;Gumiero, Daniela;D'Alo', Francesco;Guidi, Francesco;Mansueto, Giovanna Rosaria;Di Febo, Annalaura;Massini, Giuseppina;Martini, Maurizio;Larocca, Luigi Maria;Hohaus, Stefan;Leone, Giuseppe
2006

Abstract

We studied whether DAP-kinase hypermethylation plays a role as a prognostic marker in patients with follicular lymphoma (FL). We found that DAP-kinase was frequently hypermethylated in bone marrow (BM) samples of 52 FL patients at diagnosis (71%) and identified patients with worse progression-free survival (p=0.06). In particular, patients with histologically proven BM infiltration and DAP-kinase hypermethylation had a poorer outcome (p=0.037). In a total of 170 BM samples obtained at diagnosis or during follow-up, DAP-kinase hypermethylation and the bcl2/IgH rearrangement gave concordant results in 67% of samples (48% both positive, 19% both negative). Both mrakers were independent predictors of the disease status (p<0.001).
Inglese
Voso, M. T., Gumiero, D., D'alo', F., Guidi, F., Mansueto, G. R., Di Febo, A., Massini, G., Martini, M., Larocca, L. M., Hohaus, S., Leone, G., DAP-kinase hypermethylation in the bone marrow of patients with follicular lymphoma., <>, 2006; (Settembre): 1252-1256 [http://hdl.handle.net/10807/6335]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/6335
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