Introduction: We evaluated whether near infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) versus controls. IBM showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM showed reduced oxidative metabolism compared with IBM (P=0.001) and impaired ability to supply oxygen compared with PM (P= 0.03) and IBM (P= 0.001). Discussion: NIRS differentiates samples of DM and IBM patients from controls, but it cannot distinguish PM patients from a sample of healthy subjects. © 2014 Wiley Periodicals, Inc.

Caliandro, P., Mirabella, M., Padua, L., Simbolotti, C., De Fino, C., Iacovelli, C., Sancricca, C., Rossini, P. M., Idiopathic inflammatory myopathies evaluated by near infrared spectroscopy, <<MUSCLE & NERVE>>, 2014; 51 (6): 830-837. [doi:10.1002/mus.24476] [http://hdl.handle.net/10807/62754]

Idiopathic inflammatory myopathies evaluated by near infrared spectroscopy

Caliandro, Pietro;Mirabella, Massimiliano;Padua, Luca;De Fino, Chiara;Iacovelli, Chiara;Sancricca, Cristina;Rossini, Paolo Maria
2014

Abstract

Introduction: We evaluated whether near infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM). Methods: We enrolled 10 consecutive patients affected by DM, 11 by PM, 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia. Results: DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) versus controls. IBM showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM showed reduced oxidative metabolism compared with IBM (P=0.001) and impaired ability to supply oxygen compared with PM (P= 0.03) and IBM (P= 0.001). Discussion: NIRS differentiates samples of DM and IBM patients from controls, but it cannot distinguish PM patients from a sample of healthy subjects. © 2014 Wiley Periodicals, Inc.
Inglese
Caliandro, P., Mirabella, M., Padua, L., Simbolotti, C., De Fino, C., Iacovelli, C., Sancricca, C., Rossini, P. M., Idiopathic inflammatory myopathies evaluated by near infrared spectroscopy, <<MUSCLE & NERVE>>, 2014; 51 (6): 830-837. [doi:10.1002/mus.24476] [http://hdl.handle.net/10807/62754]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/62754
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