on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.
Bertuzzi, T., Bernardini, C., Grilli, E., Duvigneau, C., Zannoni, A., Tugnoli, B., Gentilini, F., Spinozzi, S., Camborata, C., Bacci, M. L., Piva, A., Forni, M., Cellular stress marker alteration and inflammatory response in pigsfed with an ochratoxin contaminated diet, <<RESEARCH IN VETERINARY SCIENCE>>, N/A; 97 (2): 244-250. [doi:10.1016/j.rvsc.2014.07.018] [http://hdl.handle.net/10807/61454]
Cellular stress marker alteration and inflammatory response in pigs fed with an ochratoxin contaminated diet
Bertuzzi, Terenzio;
2014
Abstract
on growth performances, blood parameters, systemic cytokine levels, cell stress markers and reactivity of immune system of weaned pigs. Growth performance was not affected by OTA consumption even if OTA levels increased in plasma, kidney and liver. OTA diminished the protein content in the serum and increased levels of TNF-alpha and IL-10 in plasma. HO-1 mRNA, indicative for cells stress, was decreased in the kidney but increased in the liver. Additionally, whole blood of the animals of the OTA-group showed a decreased capacity to respond with cytokine expression (mRNA and protein) to ex vivo challenge with LPS. In conclusion our findings indicate that chronic ingestion with OTA-contaminated feed, even at low level, is hazardous for the animal and virtually for human health, pig being an excellent model for human.
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