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EnglishMedd et al.,1 retrospectively studied the occurrence of paraproteinaemia after allo-SCT in a cohort of 91 patients. They detected a paraproteinaemia incidence of 32%, multiple in the majority of cases, with a predominance of an IgG isotype and with equal kappa/lambda restriction. In this report, the most important risk factor for the development of post-transplant paraproteinaemia was CMV reactivation, which was more frequent when alemtuzumab was included in conditioning regimen. The authors also described a poorer OS in patients with paraproteinaemia, with relapse being the commonest cause of death in this group of patients. None of the patients with paraproteinaemia subsequently developed myeloma or a lymphoproliferative disorder and only one patient developed cryoglobulinemia.
Metafuni, E., Giammarco, S., Bellesi, S., Chiusolo, P., Laurenti, L., Sora', F., Cattani, P., Santangelo, R., Manzara, S., Leone, G., Sica, S., Correlation between paraproteinaemia and viral reactivation after allo-SCT, <<BONE MARROW TRANSPLANTATION>>, 2012; (Febbraio): 1-1. [doi:10.1038/bmt.2012.11] [http://hdl.handle.net/10807/6027]
| Autori: | |
| Titolo: | Correlation between paraproteinaemia and viral reactivation after allo-SCT |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/bmt.2012.11 |
| Data di pubblicazione: | 2012 |
| Abstract: | Medd et al.,1 retrospectively studied the occurrence of paraproteinaemia after allo-SCT in a cohort of 91 patients. They detected a paraproteinaemia incidence of 32%, multiple in the majority of cases, with a predominance of an IgG isotype and with equal kappa/lambda restriction. In this report, the most important risk factor for the development of post-transplant paraproteinaemia was CMV reactivation, which was more frequent when alemtuzumab was included in conditioning regimen. The authors also described a poorer OS in patients with paraproteinaemia, with relapse being the commonest cause of death in this group of patients. None of the patients with paraproteinaemia subsequently developed myeloma or a lymphoproliferative disorder and only one patient developed cryoglobulinemia. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Metafuni, E., Giammarco, S., Bellesi, S., Chiusolo, P., Laurenti, L., Sora', F., Cattani, P., Santangelo, R., Manzara, S., Leone, G., Sica, S., Correlation between paraproteinaemia and viral reactivation after allo-SCT, <<BONE MARROW TRANSPLANTATION>>, 2012; (Febbraio): 1-1. [doi:10.1038/bmt.2012.11] [http://hdl.handle.net/10807/6027] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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