The virological and immunological outcomes in patients carrying multiclass-resistant HIV-1, their predictors, and their impact on disease progression were investigated. Antiretroviral-experienced patients carrying at least one primary resistance mutation (IAS-USA 2006) to two to three classes of antiretroviral drugs were analyzed for achieving an HIV-1 RNA <50 copies/ml, a CD4 count increase of >200 cells/microl from baseline, and progression to an AIDS-defining event or death. Survival analysis was performed using the Kaplan-Meier estimates and predictors of different outcomes were analyzed using Cox's regression models. A total of 236 patients were identified. Of these 73% reached HIV-1 RNA <50 copies/ml. Higher genotypic sensitivity score of the salvage regimen, lower viral load, and more recent calendar year at genotyping were independently associated with virological response. Immunological response (58%) was predicted by a more recent calendar year, the achievement of an undetectable viral load, and higher CD4 counts at genotyping. Thirty-three patients showed clinical progression: achieving HIV-1 RNA <50 copies/ml predicted AIDS-free survival, independently from other significant cofactors. In individuals with multiclass-resistant HIV-1, virological suppression and immunological recovery are becoming more easily accessible with more recent therapies. The achievement of virological suppression is a strong predictor of reduced clinical progression

Bracciale, L., Di Giambenedetto, S., Colafigli, M., La Torre, G., Prosperi, M., Santangelo, R., Marchetti, S., Cauda, R., Fadda, G., De Luca, A., Virological suppression reduces clinical progression in patients with multiclass-resistant HIV type 1, <<AIDS RESEARCH AND HUMAN RETROVIRUSES>>, 2009; (Marzo): 261-267 [http://hdl.handle.net/10807/5990]

Virological suppression reduces clinical progression in patients with multiclass-resistant HIV type 1

Bracciale;Laura; Di Giambenedetto;Simona; Colafigli;Manuela; La Torre;Mattia; Santangelo;Rosaria; Marchetti;Simona; Cauda;Roberto; Fadda;Giovanni; De Luca
2009

Abstract

The virological and immunological outcomes in patients carrying multiclass-resistant HIV-1, their predictors, and their impact on disease progression were investigated. Antiretroviral-experienced patients carrying at least one primary resistance mutation (IAS-USA 2006) to two to three classes of antiretroviral drugs were analyzed for achieving an HIV-1 RNA <50 copies/ml, a CD4 count increase of >200 cells/microl from baseline, and progression to an AIDS-defining event or death. Survival analysis was performed using the Kaplan-Meier estimates and predictors of different outcomes were analyzed using Cox's regression models. A total of 236 patients were identified. Of these 73% reached HIV-1 RNA <50 copies/ml. Higher genotypic sensitivity score of the salvage regimen, lower viral load, and more recent calendar year at genotyping were independently associated with virological response. Immunological response (58%) was predicted by a more recent calendar year, the achievement of an undetectable viral load, and higher CD4 counts at genotyping. Thirty-three patients showed clinical progression: achieving HIV-1 RNA <50 copies/ml predicted AIDS-free survival, independently from other significant cofactors. In individuals with multiclass-resistant HIV-1, virological suppression and immunological recovery are becoming more easily accessible with more recent therapies. The achievement of virological suppression is a strong predictor of reduced clinical progression
Inglese
Bracciale, L., Di Giambenedetto, S., Colafigli, M., La Torre, G., Prosperi, M., Santangelo, R., Marchetti, S., Cauda, R., Fadda, G., De Luca, A., Virological suppression reduces clinical progression in patients with multiclass-resistant HIV type 1, <<AIDS RESEARCH AND HUMAN RETROVIRUSES>>, 2009; (Marzo): 261-267 [http://hdl.handle.net/10807/5990]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/5990
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