Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.
Dei Malatesta, M., Rocca, B., Gentile, T., Hadjistilianou, T., Borri, M., De Francesco, S., Pisani, F., Famulari, A., A case of coloboma in a newborn to a woman taking mycophenolate mofetil in pregnancy after kidney transplantation., <<TRANSPLANTATION PROCEEDINGS>>, 2009; (41): 1407-1409 [http://hdl.handle.net/10807/5955]
A case of coloboma in a newborn to a woman taking mycophenolate mofetil in pregnancy after kidney transplantation.
Rocca, Bianca;
2009
Abstract
Recently, mycophenolate mofetil (MMF) has been introduced in the immunosuppressive strategy after kidney transplantation. Recently, the existence of a MMF associated embriopathy has been hypothesized, namely, multiple craniofacial malformations. Only 1 report has described chorioretinal coloboma. We report a case of woman who used MMF throughout pregnancy after kidney transplantation. Her newborn developed coloboma of the right eye associated with an ocular cyst without any other malformation. The other drugs used by our patient are not considered teratogenic. Therefore, it seems reasonable to conclude a causal relationship between MMF and the malformation observed in this newborn.
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