Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarkers (cTnT and NT-pro-BNP) in the early detection of subclinical anthracycline-induced functional alterations in children with ALL.
Ruggiero, A., De Rosa, G., Rizzo, D., Leo, A., Maurizi, P., De Nisco, A., Vendittelli, F., Zuppi, C., Mordente, A., Riccardi, R., Myocardial performance index and biochemical markers for early detection of doxorubicin-induced cardiotoxicity in children with acute lymphoblastic leukaemia, <<INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY>>, 2013; 18 (5): 927-933. [doi:10.1007/s10147-012-0458-9] [http://hdl.handle.net/10807/53458]
Myocardial performance index and biochemical markers for early detection of doxorubicin-induced cardiotoxicity in children with acute lymphoblastic leukaemia
Ruggiero, Antonio;De Rosa, Gabriella;Rizzo, Daniela;Maurizi, Palma;De Nisco, Alessia;Vendittelli, Francesca;Zuppi, Cecilia;Mordente, Alvaro;Riccardi, Riccardo
2013
Abstract
Despite significant improvements in the prognosis of childhood acute lymphoblastic leukaemia (ALL), the risk of anthracycline-induced cardiovascular disease remains a major concern. This study was designed to investigate the role of the myocardial performance index (MPI) and serum concentrations of biomarkers (cTnT and NT-pro-BNP) in the early detection of subclinical anthracycline-induced functional alterations in children with ALL.
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