Abstract BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
Mirijello, A., Addolorato, G., D'Angelo, C., Ferrulli, A., Vassallo, G. A., Antonelli, M., Leggio, L., Landolfi, R., Baclofen in the treatment of persistent hiccup: a case series., <<internal journal of clinical practice>>, 2013; (Settembre): 918-921. [doi:10.1111/ijcp.12184] [http://hdl.handle.net/10807/52842]
Baclofen in the treatment of persistent hiccup: a case series.
Mirijello, Antonio;Addolorato, Giovanni;D'Angelo, Cristina;Ferrulli, Anna;Vassallo, Gabriele Angelo;Antonelli, Mariangela;Leggio, Lorenzo;Landolfi, Raffaele
2013
Abstract
Abstract BACKGROUND: Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. AIM: To test baclofen administration for the treatment of persistent hiccup. METHOD: We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. RESULTS: Hiccup stopped in all patients after a single administration of the drug. CONCLUSIONS: Baclofen is a GABA(B) receptor agonist. It is conceivable that the reduction of dopamine release by GABA(B) receptor stimulation is able to interrupt hiccup's reflex arc.
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