The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.

D'amario, D., Leone, A. M., Iaconelli, A., Luciani, N., Gaudino, M. F. L., Kannappan, R., Manchi, M., Severino, A., Shin, S. H., Graziani, F., Biasillo, G., Macchione, A., Smaldone, C., De Maria, G. L., Cellini, C., Siracusano, A., Ottaviani, L., Massetti, M., Goichberg, P., Leri, A., Anversa, P., Crea, F., Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery, <<CIRCULATION>>, 2014; 129 (2): 157-172. [doi:10.1161/CIRCULATIONAHA.113.006591] [http://hdl.handle.net/10807/52048]

Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery

D'Amario, Domenico;Leone, Antonio Maria;Luciani, Nicola;Gaudino, Mario Fulvio Luigi;Manchi, Melissa;Severino, Anna;Graziani, Francesca;Biasillo, Gina;Macchione, Andrea;Smaldone, Costantino;De Maria, Giovanni Luigi;Cellini, Carlo;Massetti, Massimo;Crea, Filippo
2014

Abstract

The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.
Inglese
D'amario, D., Leone, A. M., Iaconelli, A., Luciani, N., Gaudino, M. F. L., Kannappan, R., Manchi, M., Severino, A., Shin, S. H., Graziani, F., Biasillo, G., Macchione, A., Smaldone, C., De Maria, G. L., Cellini, C., Siracusano, A., Ottaviani, L., Massetti, M., Goichberg, P., Leri, A., Anversa, P., Crea, F., Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery, <<CIRCULATION>>, 2014; 129 (2): 157-172. [doi:10.1161/CIRCULATIONAHA.113.006591] [http://hdl.handle.net/10807/52048]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/52048
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