Efavirenz (EFV) administration is still controversial for its high rates of interruption mainly related to central nervous system side effects (CNS-SE). Aim of the study was to define if single tablet regimen (STR) as compared to bis-in-die (BID) or once-daily (OD) with ≥2 pills-a-day EFV formulations reduced the risk of interruption.
Fabbiani, M., Zaccarelli, M., Grima, P., Prosperi, M., Fanti, I., Colafigli, M., D'Avino, A., Mondi, A., Borghetti, A., Fantoni, M., Cauda, R., Di Giambenedetto, S., Single tablet regimens are associated with reduced Efavirenz withdrawal in antiretroviral therapy naïve or switching for simplification HIV-infected patients, <<BMC PUBLIC HEALTH>>, 2014; 14 (1): 26-26. [doi:10.1186/1471-2334-14-26] [http://hdl.handle.net/10807/50891]
Single tablet regimens are associated with reduced Efavirenz withdrawal in antiretroviral therapy naïve or switching for simplification HIV-infected patients
Fabbiani, Massimiliano;Grima, Pierfrancesco;Fanti, Iuri;Colafigli, Manuela;D'Avino, Alessandro;Mondi, Annalisa;Borghetti, Alberto;Fantoni, Massimo;Cauda, Roberto;Di Giambenedetto, Simona
2014
Abstract
Efavirenz (EFV) administration is still controversial for its high rates of interruption mainly related to central nervous system side effects (CNS-SE). Aim of the study was to define if single tablet regimen (STR) as compared to bis-in-die (BID) or once-daily (OD) with ≥2 pills-a-day EFV formulations reduced the risk of interruption.
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