Study objectives: to evaluate sleep modifications induced by chronic benzodiazepines (BDZs) abuse. Methods: cohort study, comparison of sleep measures between BDZs abusers and controls. Drug Addiction Unit (Institute of Psychiatry) and Unit of Sleep Disorder (Institute of Neurology) of the Catholic University in Rome. Six outpatients were enrolled, (4 men and 2 7 women, mean age 53.3±14.8, range: 34 - 70 years) affected by BDZ chronic abuse; 55 healthy controls (23 men and 32 women, mean age 54.2 ±13.0, range: 27–76 years). All patients underwent clinical evaluation, psychometric measures, ambulatory polysomnography, scoring of sleep macrostructure and microstructure (power spectral fast-frequency EEG arousal, Cyclic Alternating Pattern - CAP), Heart Rate Variability. Results: BDZs abusers had relevant modification of sleep macrostructure and a marked reduction of fast-frequency EEG arousal in NREM (Patients: 6.6±3.7 events/hour, Controls 13.7±4.9 events/hour, U-test: 294, p=0.002) and REM (Patients: 8.4±2.4 events/hour, Controls 13.3±5.1 events/hour, U-test: 264, p=0.016), and of CAP rate (Patients: 15.0±8.6 %, Controls: 51.2±12.1 %, U-test: 325, p<0.001). Discussion: BDZs abusers have reduction of arousals associated with increased number of nocturnal awakenings and severe impairment of sleep architecture. The effect of chronic BDZs abuse on sleep may be described as a severe impairment of arousal dynamics; the result is the inability to modulate levels of vigilance.

Mazza, M., Losurdo, A., Testani, E., Marano, G., Di Nicola, M., Dittoni, S., Gnoni, V., Di Blasi, C., Giannantoni, N. M. G., Lapenta, L., Brunetti, V., Janiri, L., Bria, P., Mazza, S., Della Marca, G., Polysomnographic Findings in a Cohort of Chronic Insomnia Patients with Benzodiazepines Abuse, <<JOURNAL OF CLINICAL SLEEP MEDICINE>>, 2014; 10 (1): 35-42. [doi:10.5664/jcsm.3354] [http://hdl.handle.net/10807/50253]

Polysomnographic Findings in a Cohort of Chronic Insomnia Patients with Benzodiazepines Abuse

Mazza, Marianna;Losurdo, Anna;Testani, Elisa;Di Nicola, Marco;Dittoni, Serena;Gnoni, Valentina;Di Blasi, Chiara;Brunetti, Valerio;Janiri, Luigi;Bria, Pietro;Mazza, Salvatore;Della Marca, Giacomo
2014

Abstract

Study objectives: to evaluate sleep modifications induced by chronic benzodiazepines (BDZs) abuse. Methods: cohort study, comparison of sleep measures between BDZs abusers and controls. Drug Addiction Unit (Institute of Psychiatry) and Unit of Sleep Disorder (Institute of Neurology) of the Catholic University in Rome. Six outpatients were enrolled, (4 men and 2 7 women, mean age 53.3±14.8, range: 34 - 70 years) affected by BDZ chronic abuse; 55 healthy controls (23 men and 32 women, mean age 54.2 ±13.0, range: 27–76 years). All patients underwent clinical evaluation, psychometric measures, ambulatory polysomnography, scoring of sleep macrostructure and microstructure (power spectral fast-frequency EEG arousal, Cyclic Alternating Pattern - CAP), Heart Rate Variability. Results: BDZs abusers had relevant modification of sleep macrostructure and a marked reduction of fast-frequency EEG arousal in NREM (Patients: 6.6±3.7 events/hour, Controls 13.7±4.9 events/hour, U-test: 294, p=0.002) and REM (Patients: 8.4±2.4 events/hour, Controls 13.3±5.1 events/hour, U-test: 264, p=0.016), and of CAP rate (Patients: 15.0±8.6 %, Controls: 51.2±12.1 %, U-test: 325, p<0.001). Discussion: BDZs abusers have reduction of arousals associated with increased number of nocturnal awakenings and severe impairment of sleep architecture. The effect of chronic BDZs abuse on sleep may be described as a severe impairment of arousal dynamics; the result is the inability to modulate levels of vigilance.
Inglese
Mazza, M., Losurdo, A., Testani, E., Marano, G., Di Nicola, M., Dittoni, S., Gnoni, V., Di Blasi, C., Giannantoni, N. M. G., Lapenta, L., Brunetti, V., Janiri, L., Bria, P., Mazza, S., Della Marca, G., Polysomnographic Findings in a Cohort of Chronic Insomnia Patients with Benzodiazepines Abuse, <<JOURNAL OF CLINICAL SLEEP MEDICINE>>, 2014; 10 (1): 35-42. [doi:10.5664/jcsm.3354] [http://hdl.handle.net/10807/50253]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/50253
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact