Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).

Caliandro, P., Silvestri, G., Padua, L., Bianchi, M. L. E., Simbolotti, C., Russo, G., Masciullo, M., Rossini, P. M., fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1, <<CLINICAL NEUROPHYSIOLOGY>>, 2013; 124 (11): 2269-2276. [doi:10.1016/j.clinph.2013.05.010] [http://hdl.handle.net/10807/45679]

fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1

Caliandro, Pietro;Silvestri, Gabriella;Padua, Luca;Bianchi, Maria Laura Ester;Masciullo, Marcella;Rossini, Paolo Maria
2013

Abstract

Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).
Inglese
Caliandro, P., Silvestri, G., Padua, L., Bianchi, M. L. E., Simbolotti, C., Russo, G., Masciullo, M., Rossini, P. M., fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1, <<CLINICAL NEUROPHYSIOLOGY>>, 2013; 124 (11): 2269-2276. [doi:10.1016/j.clinph.2013.05.010] [http://hdl.handle.net/10807/45679]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/45679
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