A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).

Chiò, A., Borghero, G., Calvo, A., Capasso, M., Caponnetto, C., Corbo, M., Giannini, F., Logroscino, G., Mandrioli, J., Marcello, N., Mazzini, L., Moglia, C., Monsurrò, M., Mora, G., Patti, F., Pietrini, V., Pisano, F., Pupillo, E., Sabatelli, M., Salvi, F., Silani, V., Simone, I., Sorarù, G., Tola, M., Volanti, P., Beghi, E., Perini, M., Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial, <<NEUROLOGY>>, 2010; 75 (7): 619-625. [doi:10.1212/WNL.0b013e3181ed9e7c] [http://hdl.handle.net/10807/4501]

Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial

Sabatelli, Mario;
2010

Abstract

A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).
2010
Inglese
Chiò, A., Borghero, G., Calvo, A., Capasso, M., Caponnetto, C., Corbo, M., Giannini, F., Logroscino, G., Mandrioli, J., Marcello, N., Mazzini, L., Moglia, C., Monsurrò, M., Mora, G., Patti, F., Pietrini, V., Pisano, F., Pupillo, E., Sabatelli, M., Salvi, F., Silani, V., Simone, I., Sorarù, G., Tola, M., Volanti, P., Beghi, E., Perini, M., Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial, <<NEUROLOGY>>, 2010; 75 (7): 619-625. [doi:10.1212/WNL.0b013e3181ed9e7c] [http://hdl.handle.net/10807/4501]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/4501
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact