We describe a patient with painful neuropathy associated with an abnormal anti-MAG titer in which predominant involvement of intra-epidermal nerve fiber was documented. Electrophysiological studies revealed low-borderline amplitude of sensory and compound motor action potentials registering from lower limbs and normal conduction velocity. Sural nerve biopsy disclosed only a slight loss of myelinated fiber. Skin biopsy performed at the proximal thigh and at the distal leg was consistent with a non-length-dependent small fiber neuropathy. It is likely that in this case anti-MAG antibodies played a role in the pathogenesis of small fiber neuropathy.

Luigetti, M., Madia, F., Conte, A., Tonali, P. A., Sabatelli, M., Neuropathy with predominant small fiber involvement associated with abnormal anti-MAG titer., <<INTERNAL MEDICINE>>, N/A; 2010 (49): 2627-2629 [http://hdl.handle.net/10807/3534]

Neuropathy with predominant small fiber involvement associated with abnormal anti-MAG titer.

Luigetti, Marco;Madia, Francesca;Conte, Amelia;Tonali, Pietro Attilio;Sabatelli, Mario
2010

Abstract

We describe a patient with painful neuropathy associated with an abnormal anti-MAG titer in which predominant involvement of intra-epidermal nerve fiber was documented. Electrophysiological studies revealed low-borderline amplitude of sensory and compound motor action potentials registering from lower limbs and normal conduction velocity. Sural nerve biopsy disclosed only a slight loss of myelinated fiber. Skin biopsy performed at the proximal thigh and at the distal leg was consistent with a non-length-dependent small fiber neuropathy. It is likely that in this case anti-MAG antibodies played a role in the pathogenesis of small fiber neuropathy.
Inglese
Luigetti, M., Madia, F., Conte, A., Tonali, P. A., Sabatelli, M., Neuropathy with predominant small fiber involvement associated with abnormal anti-MAG titer., <<INTERNAL MEDICINE>>, N/A; 2010 (49): 2627-2629 [http://hdl.handle.net/10807/3534]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/3534
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