: The development of a de novo lymphoma in patients affected by chronic myelogenous leukemia (CML) is a rare event. The introduction of new molecular cytogenetic techniques, such as fluorescence in situ hybridization (FISH), allows a correct differential diagnosis between lymphoid blastic crisis and a blastoid variant of mantle cell lymphoma (MCL), which shows an aggressive behavior and some molecular characteristics detectable by cytogenetics and immunohistochemistry. We report a case of a blastoid variant of MCL that developed in a patient with CML who achieved complete cytogenetic and molecular response to imatinib mesylate treatment.
Garzia, M., Sora', F., Teofili, L., Di Mario, A., Voso, M. T., Rumi, C., La Rocca, L. M., Sica, S., Zini, G., Blastoid mantle cell lymphoma occurring in a patient in complete remission of chronic myelogenous leukemia, <<LABORATORY HEMATOLOGY>>, 2007; 13 (1): 30-33 [https://hdl.handle.net/10807/344016]
Blastoid mantle cell lymphoma occurring in a patient in complete remission of chronic myelogenous leukemia
Sora', Federica;Teofili, Luciana;Voso, Maria Teresa;Sica, Simona;
2007
Abstract
: The development of a de novo lymphoma in patients affected by chronic myelogenous leukemia (CML) is a rare event. The introduction of new molecular cytogenetic techniques, such as fluorescence in situ hybridization (FISH), allows a correct differential diagnosis between lymphoid blastic crisis and a blastoid variant of mantle cell lymphoma (MCL), which shows an aggressive behavior and some molecular characteristics detectable by cytogenetics and immunohistochemistry. We report a case of a blastoid variant of MCL that developed in a patient with CML who achieved complete cytogenetic and molecular response to imatinib mesylate treatment.
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